PARP1 Antibody (Phospho-Ser782) (OAAB16322)

Data Sheet
 
Product Number OAAB16322
Product Page www.avivasysbio.com/parp1-antibody-phospho-s782-oaab16322.html
Name PARP1 Antibody (Phospho-Ser782) (OAAB16322)
Molecular Weight 113 kDa
Isotype Ig
NCBI Gene Id 142
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols PARP, PPOL, ADPRT, ARTD1, ADPRT1, PARP-1, ADPRT 1, pADPRT-1
Product Format Liquid. PBS with 0.09% (W/V) sodium azide.
Description of Target This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16322
Additional Information Function: Involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly (ADP- ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Cellular Location: Nucleus. Nucleus, nucleolus. Note=Localizes at sites of DNA damage.
Application Info DB: 1:500
Immunogen This PARP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S782 of human PARP1.
Uniprot ID P09874
Protein Name Poly [ADP-ribose] polymerase 1
Protein Accession # NP_001609.2
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Gene Symbol PARP1
Predicted Species Reactivity Human
Application DB
Predicted Homology Based on Immunogen Sequence Bovine, Hamster, Mouse, Rat
Image 1
Phospho-peptide, non-phospho-peptide
Dot blot analysis of Phospho-PARP1-S782 Antibody Phospho-specific Pab (Cat. # OAAB16322) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
 

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