| Product Number |
OAAB16292 |
| Product Page |
www.avivasysbio.com/ikkb-antibody-phospho-s672-oaab16292.html |
| Name |
IKKB Antibody (Phospho-Ser672) (OAAB16292) |
| Molecular Weight |
87 kDa |
| Isotype |
Ig |
| NCBI Gene Id |
3551 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Description |
|
| Alias Symbols |
IKK2, IKKB, IMD15, IMD15A, IMD15B, NFKBIKB, IKK-beta |
| Product Format |
Liquid PBS with 0.09% (W/V) sodium azide. |
| Description of Target |
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). |
| Reconstitution and Storage |
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB16292 |
| Application Info |
DB: 1:500 |
| Immunogen |
This IKKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S672 of human IKKB. |
| Additional Information |
Cellular Location: Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts
Tissue Location: Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood. |
| Uniprot ID |
O14920 |
| Protein Name |
Inhibitor of nuclear factor kappa-B kinase subunit beta |
| Protein Accession # |
NP_001177649.1 |
| Purification |
This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Gene Symbol |
IKBKB |
| Predicted Species Reactivity |
Human |
| Application |
DB, ELISA |
| Image 1 | Phospho-peptide, non-phospho-peptide
 | Dot blot analysis of Phospho-IKKB-S672 Antibody Phospho-specific Pab (Cat. # OAAB16292) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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