ERBB2 Antibody (Phospho-Tyr1197) (OAAB16280)

Data Sheet
 
Product Number OAAB16280
Product Page www.avivasysbio.com/erbb2-antibody-phospho-y1197-oaab16280.html
Name ERBB2 Antibody (Phospho-Tyr1197) (OAAB16280)
Molecular Weight 138579 Da
Isotype Ig
NCBI Gene Id 13866
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols Ne, HER, Neu, HER-, HER2, c-ne, ErbB-, HER-2, c-neu, l11Ju, Erbb-2, c-erbB, c-erbB2, l11Jus8, mKIAA3023
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Description of Target Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16280
Additional Information Precautions: Phospho-mouse ERBB2-Y1197 is for research use only and not for use in diagnostic or therapeutic procedures.
Additional Information Function: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity)
Application Info DB: 1:500
Immunogen This mouse ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1197 of mouse ERBB2.
Additional Information Cellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity)
Tissue Location: Expressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers
Uniprot ID P70424
Protein Name Receptor tyrosine-protein kinase erbB-2
Protein Accession # NP_001003817.1
Gene Symbol Erbb2
Predicted Species Reactivity Mouse
Application DB
Predicted Homology Based on Immunogen Sequence Mouse
Image 1
Phospho-peptide, non-phospho-peptide
Dot blot analysis of Phospho-mouse ERBB2-Y1197 Antibody Phospho-specific Pab (Cat. # OAAB16280) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.
 

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