| Product Number |
OAAB16261 |
| Product Page |
www.avivasysbio.com/casp3-antibody-phospho-s12-oaab16261.html |
| Name |
CASP3 Antibody (Phospho-Ser12) (OAAB16261) |
| Molecular Weight |
31475 Da |
| Isotype |
Ig |
| NCBI Gene Id |
12367 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
Ya, AC-, CC3, CPP, mld, AC-3, Casp, Lice, Yama, mldy, CPP32, SCA-1, CASP-3, CPP-32, Caspase-3, A830040C14Rik |
| Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB16261 |
| Additional Information |
Precautions: Phospho-mouse CASP3-S12 is for research use only and not for use in diagnostic or therapeutic procedures. |
| Additional Information |
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly (ADP-ribose) polymerase (PARP) at a '216-Asp-l-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity) Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes |
| Application Info |
DB: 1:500 |
| Immunogen |
This mouse CASP3 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S12 of mouse CASP3. |
| Additional Information |
Cellular Location: Cytoplasm.
Tissue Location: Highest expression in spleen, lung, liver, kidney and heart. Lower expression in brain, skeletal muscle and testis |
| Uniprot ID |
P70677 |
| Protein Name |
Caspase-3 |
| Protein Accession # |
NP_033940.1 |
| Gene Symbol |
Casp3 |
| Predicted Species Reactivity |
Mouse |
| Application |
DB |
| Predicted Homology Based on Immunogen Sequence |
Mouse |
| Image 1 | Phospho-peptide, non-phospho-peptide
 | Dot blot analysis of Phospho-mouse CASP3-S12 Antibody Phospho-specific Pab (Cat. # OAAB16261) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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