Product Number |
OAAB16247 |
Product Page |
www.avivasysbio.com/bad-antibody-phospho-t137-oaab16247.html |
Name |
BAD Antibody (Phospho-Thr137) (OAAB16247) |
Molecular Weight |
18392 Da |
Isotype |
Ig |
NCBI Gene Id |
572 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Alias Symbols |
BBC2, BCL2L8 |
Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB16247 |
Additional Information |
Precautions: Phospho-BAD-T137 is for research use only and not for use in diagnostic or therapeutic procedures. |
Additional Information |
Function: Promotes cell death. Successfully competes for the binding to Bcl-X (L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X (L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways |
Application Info |
DB: 1:500 |
Immunogen |
This BAD Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T137 of human BAD. |
Additional Information |
Cellular Location: Mitochondrion outer membrane. Cytoplasm. Note=Upon phosphorylation, locates to the cytoplasm Tissue Location: Expressed in a wide variety of tissues. |
Uniprot ID |
Q92934 |
Protein Name |
Bcl2 antagonist of cell death |
Protein Accession # |
NP_004313.1 |
Gene Symbol |
BAD |
Predicted Species Reactivity |
Human |
Application |
DB |
Predicted Homology Based on Immunogen Sequence |
Human |
Image 1 | Phospho-peptide, non-phospho-peptide
| Dot blot analysis of Phospho-BAD-T137 Antibody Phospho-specific Pab (Cat. # OAAB16247) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml. |
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