MEF2C Antibody (Phospho-Thr300) (OAAB16207)

• Product Number: OAAB16207
• Name: MEF2C Antibody (Phospho-Thr300) (OAAB16207)
• Molecular Weight: 51221 Da
• Isotype: Ig
• NCBI Gene Id: 4208
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Alias Symbols: DEL5q14.3, C5DELq14.3
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Description of Target: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Additional Information: Precautions: Phospho-MEF2C-T300 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
• Additional Information: Function: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2
• Application Info: DB: 1:500
• Immunogen: This MEF2C Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T300 of human MEF2C.
• Additional Information: Cellular Location: Nucleus.
  Tissue Location: Expressed in brain and skeletal muscle.
• Uniprot ID: Q06413
• Protein Name: Myocyte-specific enhancer factor 2C
• Protein Accession #: NP_001124477.1
• Gene Symbol: MEF2C
• Predicted Species Reactivity: Human
• Application: DB
• Predicted Homology Based on Immunogen Sequence: Human
• Image 1: Phospho-peptide, non-phospho-peptide
  
  Dot blot analysis of Phospho-MEF2C-T300 Antibody (Cat. # OAAB16207) and MEF2C Non Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.