FAS Antibody (Phospho-Tyr291) (OAAB16151)

• Product Number: OAAB16151
• Name: FAS Antibody (Phospho-Tyr291) (OAAB16151)
• Molecular Weight: 37732 Da
• Isotype: Ig
• NCBI Gene Id: 355
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Alias Symbols: APT1, CD95, FAS1, APO-1, FASTM, ALPS1A, TNFRSF6
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Description of Target: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Additional Information: Precautions: Phospho-FAS-Y291 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
• Additional Information: Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro)
• Application Info: DB: 1:500
• Immunogen: This FAS Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y291 of human FAS.
• Additional Information: Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted. Isoform 5: Secreted.
  Tissue Location: Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6
• Uniprot ID: P25445
• Protein Name: Tumor necrosis factor receptor superfamily member 6
• Protein Accession #: NP_000034.1
• Gene Symbol: FAS
• Predicted Species Reactivity: Human
• Application: DB
• Predicted Homology Based on Immunogen Sequence: Human
• Image 1: Phospho-peptide, non-phospho-peptide
  
  Dot blot analysis of Phospho-FAS-Y291 polyclonal antibody (Cat# OAAB16151) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5ug per ml. P-Pab: phospho-antibody; P-Peptide: phospho-peptide; NP-Peptide: non-phospho-peptide.