MECP2 Antibody (Phospho-Ser292) (OAAB16065)

Data Sheet
 
Product Number OAAB16065
Product Page www.avivasysbio.com/mecp2-antibody-phospho-s292-oaab16065.html
Name MECP2 Antibody (Phospho-Ser292) (OAAB16065)
Molecular Weight 52441 Da
Isotype Ig
NCBI Gene Id 4204
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols RS, RTS, RTT, PPMX, MRX16, MRX79, MRXSL, AUTSX3, MRXS13
Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Description of Target Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB16065
Additional Information Precautions: Phospho-MECP2-pS292 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Additional Information Function: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A
Application Info IHC-P: 1:50~100
Immunogen This MECP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S292 of human MECP2.
Additional Information Cellular Location: Nucleus. Note=Colocalized with methyl-CpG in the genome
Tissue Location: Present in all adult somatic tissues tested.
Uniprot ID P51608
Protein Name Methyl-CpG-binding protein 2
Protein Accession # NP_001104262.1
Gene Symbol MECP2
Predicted Species Reactivity Human
Application IHC
Predicted Homology Based on Immunogen Sequence Human
Image 1
breast carcinoma
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
 

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