USP22 Antibody - C-terminal region (OAAB15765)

• Product Number: OAAB15765
• Name: USP22 Antibody - C-terminal region (OAAB15765)
• Molecular Weight: 59961 Da
• Isotype: Ig
• NCBI Gene Id: 23326
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Alias Symbols: USP3L
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Additional Information: Precautions: USP22 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
• Additional Information: Function: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression
• Application Info: WB: 1:1000
  IHC-P: 1:50~100
• Immunogen: This USP22 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-380 amino acids from the C-terminal region of human USP22.
• Additional Information: Cellular Location: Nucleus (Probable).
  Tissue Location: Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver
• Uniprot ID: Q9UPT9
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 22
• Sample Type Confirmation:

  USP22 is supported by BioGPS gene expression data to be expressed in Jurkat

• Protein Accession #: NP_056091.1
• Gene Symbol: USP22
• Predicted Species Reactivity: Human, Mouse, Cow, Zebrafish
• Application: IHC-P, WB
• Predicted Homology Based on Immunogen Sequence: Cow; Human; Mouse; Zebrafish
• Image 1: Jurkat
  
  Western blot analysis of USP22 Antibody (C-term) (Cat. # OAAB15765) in Jurkat cell line lysates (35ug/lane). USP22 (arrow) was detected using the purified Pab.

  USP22 is supported by BioGPS gene expression data to be expressed in Jurkat

• Image 2: breast carcinoma
  
  Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.