ANO1 Antibody - middle region (OAAB13882)

Data Sheet
 
Product Number OAAB13882
Product Page www.avivasysbio.com/ano1-antibody-center-region-oaab13882.html
Name ANO1 Antibody - middle region (OAAB13882)
Molecular Weight 114078 Da
Isotype Ig
NCBI Gene Id 55107
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Alias Symbols DOG1, TAOS2, ORAOV2, TMEM16A
Product Format Liquid. PBS with 0.09% (W/V) sodium azide.
Description of Target ANO1 acts as a calcium-activated chloride channel. Required for normal tracheal development.
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB13882
Additional Information Function: Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Cellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors
Tissue Location: Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles
Application Info WB: 1:1000
Immunogen This ANO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the Central region of human ANO1.
Intended Use ANO1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Uniprot ID Q5XXA6
Protein Name Anoctamin-1
Publications

Yin, L. et al. Glucose stimulates calcium-activated chloride secretion in small intestinal cells. Am. J. Physiol. Cell Physiol. 306, C687-96 (2014). 24477233

Protein Accession # NP_060513.5
Purification This antibody is purified through a protein A column, followed by peptide affinity purification
Gene Symbol ANO1
Predicted Species Reactivity Human
Application WB
Predicted Homology Based on Immunogen Sequence Human
Image 1
K562
ANO1 Antibody (Center) (Cat. # OAAB13882) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ANO1 Antibody detected the ANO1 protein (arrow).
 

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