Product Number |
OAAB13882 |
Product Page |
www.avivasysbio.com/ano1-antibody-center-region-oaab13882.html |
Name |
ANO1 Antibody - middle region (OAAB13882) |
Molecular Weight |
114078 Da |
Isotype |
Ig |
NCBI Gene Id |
55107 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
Alias Symbols |
DOG1, TAOS2, ORAOV2, TMEM16A |
Product Format |
Liquid. PBS with 0.09% (W/V) sodium azide. |
Description of Target |
ANO1 acts as a calcium-activated chloride channel. Required for normal tracheal development. |
Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB13882 |
Additional Information |
Function: Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Cellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Cytoplasmic localization seen in neoplastic cells of head and neck squamous cell carcinoma (HNSCC) tumors Tissue Location: Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles |
Application Info |
WB: 1:1000 |
Immunogen |
This ANO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the Central region of human ANO1. |
Intended Use |
ANO1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Uniprot ID |
Q5XXA6 |
Protein Name |
Anoctamin-1 |
Publications |
Yin, L. et al. Glucose stimulates calcium-activated chloride secretion in small intestinal cells. Am. J. Physiol. Cell Physiol. 306, C687-96 (2014). 24477233 |
Protein Accession # |
NP_060513.5 |
Purification |
This antibody is purified through a protein A column, followed by peptide affinity purification |
Gene Symbol |
ANO1 |
Predicted Species Reactivity |
Human |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Human |
Image 1 | K562
| ANO1 Antibody (Center) (Cat. # OAAB13882) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ANO1 Antibody detected the ANO1 protein (arrow). |
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