TARDBP Antibody - N-terminal region (OAAB10063)

Data Sheet
 
Product Number OAAB10063
Product Page www.avivasysbio.com/tardbp-antibody-n-terminal-region-oaab10063.html
Name TARDBP Antibody - N-terminal region (OAAB10063)
Molecular Weight 45 kDa
Isotype Ig
NCBI Gene Id 23435
Host Rabbit
Clonality Polyclonal
Concentration Varies by lot. See vial for concentration.
Alias Symbols ALS10, TDP-43
Product Format Liquid. PBS with 0.09% (W/V) sodium azide.
Description of Target HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Reconstitution and Storage Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for OAAB10063
Additional Information Cellular Location: Nucleus. Cytoplasm. Cytoplasm, Stress granule Note=Continuously travels in and out of the nucleus. Localizes to stress granules in response to oxidative stress.
Tissue Location: Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.
Application Info WB: 1:2000
IF: 1:10~50
IHC-P: 1:100
Immunogen This TARDBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TARDBP.
Intended Use TARDBP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Uniprot ID Q13148
Protein Name TAR DNA-binding protein 43
Protein Accession # NP_031401.1
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Tested Species Reactivity Human, Mouse, Rat
Gene Symbol TARDBP
Application WB, IHC-P, IF
Predicted Homology Based on Immunogen Sequence Chicken
Image 1
Hela cell
Image 2
Hela cell, mouse brain
TARDBP Antibody (N-term) (Cat. #OAAB10063) western blot analysis in Hela cell line and mouse brain lysates (35ug/lane).This demonstrates the TARDBP antibody detected the TARDBP protein (arrow).
Image 3
human colon tissue
TARDBP Antibody (N-term) (Cat. #OAAB10063)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TARDBP Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
 

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