Product Number |
OAAB10063 |
Product Page |
www.avivasysbio.com/tardbp-antibody-n-terminal-region-oaab10063.html |
Name |
TARDBP Antibody - N-terminal region (OAAB10063) |
Molecular Weight |
45 kDa |
Isotype |
Ig |
NCBI Gene Id |
23435 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
Varies by lot. See vial for concentration. |
Alias Symbols |
ALS10, TDP-43 |
Product Format |
Liquid. PBS with 0.09% (W/V) sodium azide. |
Description of Target |
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. |
Reconstitution and Storage |
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for OAAB10063 |
Additional Information |
Cellular Location: Nucleus. Cytoplasm. Cytoplasm, Stress granule Note=Continuously travels in and out of the nucleus. Localizes to stress granules in response to oxidative stress. Tissue Location: Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. |
Application Info |
WB: 1:2000 IF: 1:10~50 IHC-P: 1:100 |
Immunogen |
This TARDBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TARDBP. |
Intended Use |
TARDBP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Uniprot ID |
Q13148 |
Protein Name |
TAR DNA-binding protein 43 |
Protein Accession # |
NP_031401.1 |
Purification |
This antibody is purified through a protein A column, followed by peptide affinity purification. |
Tested Species Reactivity |
Human, Mouse, Rat |
Gene Symbol |
TARDBP |
Application |
WB, IHC-P, IF |
Predicted Homology Based on Immunogen Sequence |
Chicken |
Image 1 | Hela cell
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| Image 2 | Hela cell, mouse brain
| TARDBP Antibody (N-term) (Cat. #OAAB10063) western blot analysis in Hela cell line and mouse brain lysates (35ug/lane).This demonstrates the TARDBP antibody detected the TARDBP protein (arrow). |
| Image 3 | human colon tissue
| TARDBP Antibody (N-term) (Cat. #OAAB10063)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TARDBP Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. |
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