| Product Number |
OAAB08316 |
| Product Page |
www.avivasysbio.com/suv4-20h1-antibody-c-terminal-region-oaab08316.html |
| Name |
SUV4-20H1 Antibody - C-terminal region (OAAB08316) |
| Molecular Weight |
99187 Da |
| Isotype |
Ig |
| NCBI Gene Id |
51111 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
CGI85, MRD51, CGI-85, SUV420H1 |
| Product Format |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Description of Target |
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) |
| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for OAAB08316 |
| Additional Information |
Precautions: SUV4-20H1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Additional Information |
Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity) |
| Application Info |
WB: 1:500
WB: 1:1000
FC: 1:10~50 |
| Immunogen |
This SUV4-20H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 759-789 amino acids from the C-terminal region of human SUV4-20H1. |
| Additional Information |
Cellular Location: Nucleus. Chromosome (By similarity). Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity) |
| Uniprot ID |
Q4FZB7 |
| Protein Name |
Histone-lysine N-methyltransferase SUV420H1 |
| Protein Accession # |
NP_057112.3 |
| Gene Symbol |
SUV420H1 |
| Predicted Species Reactivity |
Human |
| Application |
WB, FC |
| Predicted Homology Based on Immunogen Sequence |
Human |
| Image 1 | HepG2
 | SUV4-20H1 Antibody (C-term) (Cat. #OAAB08316) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. |
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| Image 2 | HepG2
 | SUV4-20H1 Antibody (C-term) (Cat. #OAAB08316) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the SUV4-20H1 antibody detected the SUV4-20H1 protein (arrow). |
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