CYP26B1 Antibody - C-terminal region (OAAB05042)

• Name: CYP26B1 Antibody - C-terminal region (OAAB05042)
• Molecular Weight: 57513
• Isotype: Rabbit Ig
• NCBI Gene Id: 232174|312495|56603
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Alias Symbols: CP2, CP26, CYP26A2, Cytochrome P450 26A2, cytochrome P450 26B1, cytochrome P450 family 26 subfamily A member 1, cytochrome P450 retinoic acid-inactivating 2, cytochrome P450 retinoid metabolizing protein, cytochrome P450, 26, retinoic acid B1, cytochrome P450, family 26, subfamily B, polypeptide 1, cytochrome P450, subfamily XXVIB, polypeptide 1, cytochrome P450RAI-2, P450R, P450RAI-2, P450RAI2, retinoic acid B1, retinoic acid hydroxylase, retinoic acid-metabolizing cytochrome, RHFCA.
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Description of Target: Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (By similarity).|Involved in the metabolism of retinoic acid (RA), rendering this classical morphogen inactive through oxidation. Involved in the specific inactivation of all-trans-retinoic acid (all-trans-RA), with a preference for the following substrates: all-trans-RA > 9-cis-RA > 13-cis-RA. Generates several hydroxylated forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA. Essential for postnatal survival. Plays a central role in germ cell development: acts by degrading RA in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Application Info: WB: 1:1000
  IHC-P: 1:10~50
• Immunogen: This CYP26B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 398-430 amino acids from the C-terminal region of human CYP26B1.
• Uniprot ID: G3V7X8|Q811W2|Q9NR63
• Protein Name: Cytochrome P450 26B1|cytochrome P450 26B1 isoform 1 [Homo sapiens]|cytochrome P450 26B1 isoform 2 [Homo sapiens]
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_001264671.1,NP_063938.1
• Gene Symbol: CYP26B1
• Predicted Species Reactivity: Human|Mouse|Rat
• Application: IHC-P,WB
• Predicted Homology Based on Immunogen Sequence: Human
• Image 1: 293
  
  Western blot analysis of anti-CYP26B1 Antibody (C-term) in 293 cell lysates (35ug/lane). CYP26B1(arrow) was detected using the purified Pab.
• Image 2: CYP26B1
  
  Western blot analysis of CYP26B1 (arrow) using rabbit polyclonal CYP26B1 Antibody (C-term) either nontransfected (Lane 1) or lysates transiently transfected transfected (Lane 2) with the CYP26B1 gene.
• Image 3: human brain
  
  Formalin-fixed and paraffin-embedded human brain tissue reacted with CYP26B1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.