| Product Number |
OAAB04736 |
| Product Page |
www.avivasysbio.com/ddr1-antibody-oaab04736.html |
| Name |
DDR1 Antibody (OAAB04736) |
| Molecular Weight |
101127 Da |
| Isotype |
Rabbit Ig |
| NCBI Gene Id |
780 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
Approximately 0.5mg/ml. Actual concentration varies with each lot. |
| Alias Symbols |
CAK, DDR, NEP, HGK2, PTK3, RTK6, TRKE, CD167, EDDR1, MCK10, NTRK4, PTK3A |
| Product Format |
Liquid. PBS with 0.09% (W/V) sodium azide. |
| Description of Target |
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. MCK10 is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.
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| Reconstitution and Storage |
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-DDR1 antibody - OAAB04736 |
| Application Info |
WB: 1:1000
IHC-P: 1:10~50 |
| Immunogen |
This MCK10 antibody is generated from rabbits immunized with recombinant human MCK10 protein. |
| Uniprot ID |
Q08345 |
| Protein Name |
Epithelial discoidin domain-containing receptor 1 |
| Protein Accession # |
NP_001189450.1 |
| Purification |
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Gene Symbol |
DDR1 |
| Predicted Species Reactivity |
Human |
| Application |
WB, IHC-P |
| Predicted Homology Based on Immunogen Sequence |
Human |
| Image 1 | SK-BR-3
 | Western blot analysis of anti-MCK10 Pab in SK-BR-3 cell lysates (35ug/lane).MCK10 (arrow) was detected using the purified Pab (1:60 dilution). |
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