BICC1 Antibody - N-terminal region (OAAB04089)

Data Sheet
 
Product Number OAAB04089
Product Page www.avivasysbio.com/bicc1-antibody-n-terminal-region-oaab04089.html
Name BICC1 Antibody - N-terminal region (OAAB04089)
Molecular Weight 105 kDa
Isotype Ig
NCBI Gene Id 80114
Host Rabbit
Clonality Polyclonal
Concentration 0.47 mg/ml
Alias Symbols BICC, CYSRD
Product Format Liquid. PBS with 0.09% (W/V) sodium azide.
Reference Grupe,A., et.al., Am. J. Hum. Genet. 78 (1), 78-88 (2006)
Description of Target BICC1 is an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product.
Reconstitution and Storage Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-BICC1 antibody - OAAB04089
Additional Information Function: Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
Cellular Location: Cytoplasm
Application Info WB: 1:1000
IHC-P: 1:10~50
Optimal dilutions should be determined by the end user.
Immunogen This BICC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the N-terminal region of human BICC1.
Intended Use For research use only and not for use in diagnostic or therapeutic procedures.
Uniprot ID Q9H694
Protein Name Protein bicaudal C homolog 1
Publications

Bicaudal C mutation causes myc and TOR pathway up-regulation and polycystic kidney disease-like phenotypes in Drosophila. PLoS Genet. 13, e1006694 (2017). 28406902

Protein Accession # NP_001073981.1
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Gene Symbol BICC1
Predicted Species Reactivity Human, Mouse, Xenopus
Application WB, IHC-P
Image 1
human brain tissue
Formalin-fixed and paraffin-embedded human brain tissue reacted with BICC1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Image 2
HL-60 cell
Western blot analysis of BICC1 Antibody (N-term) (Cat. #OAAB04089) in HL-60 cell line lysates (35ug/lane). BICC1 (arrow) was detected using the purified Pab.
 

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