DCD Antibody - C-terminal region (OAAB03786)

• Product Number: OAAB03786
• Name: DCD Antibody - C-terminal region (OAAB03786)
• Molecular Weight: 11 kDa
• Isotype: Rabbit Ig
• NCBI Gene Id: 117159
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 2 mg/ml
• Alias Symbols: PIF, AIDD, DSEP, HCAP, DCD-1
• Product Format: Liquid PBS with 0.09% (W/V) sodium azide.
• Description of Target: DCD is a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients.
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Additional Information: Cellular Location: Secreted.
  Tissue Location: Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.
• Application Info: WB: 1:1000
  IHC-P: 1:50~100
  FC: 1:10~50
• Other Applications Image 1 Data: DCD Antibody (C-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
• Immunogen: This DCD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 74-103 amino acids from the C-terminal region of human DCD.
• Uniprot ID: P81605
• Protein Name: Dermcidin
• Protein Accession #: NP_444513.1
• Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Gene Symbol: DCD
• Predicted Species Reactivity: Human
• Application: WB, FC, IHC-P
• Image 1: T47D
  
  Western blot analysis of DCD antibody (C-term) in T47D cell lysates (35ug/lane). DCD (arrow) was detected using the purified Pab.
• Image 2: Human Skin
  
  DCD Antibody (C-term) (RB18706) IHC analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DCD Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
• Image 3: 293
  
  DCD Antibody (C-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.