ATP11C Antibody - middle region (OAAB02861)

Data Sheet
 
Product Number OAAB02861
Product Page www.avivasysbio.com/atp11c-antibody-center-region-oaab02861.html
Name ATP11C Antibody - middle region (OAAB02861)
Gene Symbol ATP11C
Alias Symbols ATP11C, ATPIQ, ATPIG, Probable phospholipid-transporting ATPase IG
Molecular Weight 129477 Da
Product Format Liquid. PBS with 0.09% (W/V) sodium azide.
Isotype Rabbit Ig
NCBI Gene Id 286410
Host Rabbit
Clonality Polyclonal
Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot.
Reconstitution and Storage Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-ATP11C antibody - OAAB02861
Additional Information Function: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage. Seems to mediate phosphatidylserine (PS) flipping in pro-B cells. May be involved in the transport of cholestatic bile acids (By similarity).
Cellular Location: Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Some cell membrane localization observed in the presence of TMEM30B.
Tissue Location Widely expressed.
Application Info WB: 1:1000
IHC-P: 1:50~100
FC: 1:10~50
Other Applications Image 1 Data ATP11C Antibody (Center) flow cytometric analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Immunogen This ATP11C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of human ATP11C.
Intended Use
For research use only and not for use in diagnostic or therapeutic procedures.
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express ATP11C.
Swissprot Id Q8NB49
Protein Name Probable phospholipid-transporting ATPase IG
Protein Accession # NP_001010986.1
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express ATP11C.
Replacement Item This antibody may replace item sc-141337 from Santa Cruz Biotechnology.
Predicted Species Reactivity Human, Mouse, Hamster
Application WB, FC, IHC-P
Predicted Homology Based on Immunogen Sequence Human; Mouse, Hamster
Image 1
Mouse Lung
ATP11C Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the ATP11C antibody detected ATP11C protein (arrow).
Image 2
CHO
ATP11C Antibody (Center) western blot analysis in CHO cell lysates (35ug/lane).This demonstrates the ATP11C antibody detected the ATP11C protein (arrow).
Image 3
human prostate carcinoma
ATP11C Antibody (Center immunohistochemistry analysis in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the ATP11C Antibody (Center for immunohistochemistry. Clinical relevance has not been evaluated.
Image 4
293
ATP11C Antibody (Center) flow cytometric analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
 

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