| Product Number |
AVARP13091_P050 |
| Product Page |
www.avivasysbio.com/stx1a-antibody-n-terminal-region-avarp13091-p050.html |
| Name |
STX1A Antibody - N-terminal region (AVARP13091_P050) |
| Protein Size (# AA) |
288 amino acids |
| Molecular Weight |
33kDa |
| NCBI Gene Id |
6804 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Syntaxin 1A (brain) |
| Alias Symbols |
STX1, HPC-1, P35-1, SYN1A |
| Peptide Sequence |
Synthetic peptide located within the following region: KDRTQELRTAKDSDDDDDVAVTVDRDRFMDEFFEQVEEIRGFIDKIAENV |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Kawashima,K., (er) Am. J. Med. Genet. B Neuropsychiatr. Genet. (2008) In press |
| Description of Target |
Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis. Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1253 BC064644.1 1-1253 1254-2117 BC000444.2 1209-2072 |
| Protein Interactions |
STXBP1; SUMO1P1; TXLNA; TXLNB; NAPB; VAMP5; SNAP29; VAPB; SNAP23; STX1A; PSMA3; KCNB1; Htt; SNAP25; SLC6A3; SLC6A2; PPP1CA; pnut; Sep1; SNPH; TRDMT1; CCSER2; VPS11; SYT7; VPS18; RIMS1; CPLX1; SLC6A5; STXBP5; SYTL4; STXBP6; UNC13B; STX8; RAB27A; NAPA; VAMP |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-STX1A (AVARP13091_P050) antibody |
| Blocking Peptide |
For anti-STX1A (AVARP13091_P050) antibody is Catalog # AAP30760 (Previous Catalog # AAPP01421) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human STX1A |
| Uniprot ID |
Q16623 |
| Protein Name |
Syntaxin-1A |
| Protein Accession # |
NP_004594 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_004603 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
STX1A |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100% |
| Image 1 | Human 721_B
 | WB Suggested Anti-STX1A Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: 721_B cell lysate |
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