STAT3 Antibody - middle region (AVARP09057_P050)

• Product Number: AVARP09057_P050
• Name: STAT3 Antibody - middle region (AVARP09057_P050)
• Protein Size (# AA): 770 amino acids
• Molecular Weight: 88kDa
• NCBI Gene Id: 6774
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Signal transducer and activator of transcription 3 (acute-phase response factor)
• Alias Symbols: APRF, HIES, ADMIO, ADMIO1
• Peptide Sequence: Synthetic peptide located within the following region: FGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLD
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Ohbayashi,N., (2008) Biochem. Biophys. Res. Commun. 371 (4), 823-828
• Description of Target: STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act a
• Protein Interactions: MTOR; GADD45A; BMX; BLK; UBC; SYK; LMO2; SRI; HIC1; GNB2; USP22; RELA; COPS5; BRD4; ADRB2; PSMG3; TBCD; TBC1D15; PUS7; LUC7L2; ARFIP1; IVNS1ABP; MSH2; BMH1; SIN3A; EGFR; PIAS3; HDAC3; SRC; LYN; JAK3; JAK2; HES5; TRIM28; HES1; HCK; FYN; FGR; HNRNPM; SULT2A
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Enhanced Validation:

  WB	Y
  SPR
  YCHAROS

• Additional Information: IHC Information: Uterus
  IHC Information: Thymus
• Blocking Peptide: For anti-STAT3 (AVARP09057_P050) antibody is Catalog # AAP30616 (Previous Catalog # AAPP01269)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human STAT3
• Uniprot ID: P40763
• Protein Name: Signal transducer and activator of transcription 3
• Publications:

  Tissue-specific transcription profile of cytokine and chemokine genes associated with flavivirus control and non-lethal neuropathogenesis in rabbits. Virology. 494, 1-14 (2016). 27061052

• Sample Type Confirmation:

  STAT3 is strongly supported by BioGPS gene expression data to be expressed in 721_B

• Protein Accession #: NP_644805
• Purification: Affinity Purified
• Nucleotide Accession #: NM_139276
• Tested Species Reactivity: Human
• Gene Symbol: STAT3
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep
• Application: IHC, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 93%
• Image 1: Human Thymus
  
  Immunohistochemistry with Thymus tissue at an antibody concentration of 5.0ug/ml using anti-STAT3 antibody (AVARP09057_P050)
• Image 2: Human Uterus
  
  Human Uterus
• Image 3: Human 721_B
  
  WB Suggested Anti-STAT3 Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:12500
  Positive Control: 721_B cell lysateSTAT3 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells