NFKB1 Antibody - middle region (AVARP09048_P050)

Data Sheet
 
Product Number AVARP09048_P050
Product Page www.avivasysbio.com/nfkb1-antibody-middle-region-avarp09048-p050.html
Name NFKB1 Antibody - middle region (AVARP09048_P050)
Protein Size (# AA) 969 amino acids
Molecular Weight 105kDa
NCBI Gene Id 4790
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Alias Symbols KBF1, EBP-1, NF-kB, CVID12, NF-kB1, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B1, NF-kappabeta
Peptide Sequence Synthetic peptide located within the following region: LRDSDSVCDSGVETSFRKLSFTESLTSGASLLTLNKMPHDYGQEGPLEGK
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Droll,L., (2008) Biochem. Biophys. Res. Commun. 371 (4), 626-629
Description of Target NFKB1 is a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B.This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Interactions FBXW11; UBC; RELB; RELA; REL; NFKB2; HDAC1; BCL3; NFKB1; RPS3; HIF1AN; NFKBIA; MPP6; PELP1; PLD3; MXD3; IKBKG; RL2; TP63; SRF; MAP3K8; PML; SERPINA3; SPPL2A; TNIP2; NFKBIZ; COPS5; YWHAQ; RGS14; NR4A1; GLUL; ABCC2; TNIP1; COPB2; YY1; PARP1; RPS6KA5; BTRC;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-NFKB1 (AVARP09048_P050) antibody
Blocking Peptide For anti-NFKB1 (AVARP09048_P050) antibody is Catalog # AAP30581 (Previous Catalog # AAPP01233)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human NFKB1
Uniprot ID P19838-2
Protein Name Nuclear factor NF-kappa-B p105 subunit
Protein Accession # NP_003989
Purification Affinity Purified
Nucleotide Accession # NM_003998
Tested Species Reactivity Human
Gene Symbol NFKB1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 92%; Dog: 85%; Horse: 85%; Human: 100%; Mouse: 85%; Pig: 92%; Rabbit: 85%; Rat: 78%
Image 1
Human THP-1
WB Suggested Anti-NFKB1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: THP-1 cell lysate
 

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