||CAV2 antibody - N-terminal region (AVARP09020_P050)
|Protein Size (# AA)
||162 amino acids
||Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
|NCBI Gene Id
||Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
|Official Gene Full Name
||This is a rabbit polyclonal antibody against CAV2. It was validated on Western Blot using a cell lysate as a positive control. Aviva Systems Biology strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (firstname.lastname@example.org).
||Synthetic peptide located within the following region: LVIPYNEKPEKPAKTQKTSLDEALQWRDSLDKLLQNNYGLASFKSFLKSE
||Sowa,G., (2008) Biochemistry 47 (1), 101-111
|Description of Target
||CAV2 is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Two transcript variants encoding distinct isoforms have been identified for this gene. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by one transcript.
||EGFR; PTGS1; CSNK2A1; CAV1; MALL; KCNMA1; UBC; DNAJA1; GOLGB1; NCK1; SRC; RASA1; FLOT2; DRD1; PLD2;
|Reconstitution and Storage
||For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
||Domestic: within 1-2 days delivery International: 1-2 days
||For anti-CAV2 (AVARP09020_P050) antibody is Catalog # AAP30145 (Previous Catalog # AAPP00302)
||The immunogen is a synthetic peptide directed towards the N terminal region of human CAV2
|Complete computational species homology data
||Find tissues and cell lines supported by DNA array analysis to express CAV2.
Chi Sabins, N. et al. DLK1: a novel target for immunotherapeutic remodeling of the tumor blood vasculature. Mol. Ther. 21, 1958-68 (2013). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep 23896726
|Protein Accession #
||Find tissues and cell lines supported by RNA-seq analysis to express CAV2.
|Nucleotide Accession #
||This antibody may replace item sc-7942 from Santa Cruz Biotechnology.
|Tested Species Reactivity
|Predicted Species Reactivity
||Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Sheep
|Predicted Homology Based on Immunogen Sequence
||Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%
|Human Lung||WB Suggested Anti-CAV2 Antibody Titration: 0.2-1 ug/ml|
ELISA Titer: 1:62500
Positive Control: Human Lung
|Human placenta||Lanes: |
Lane1: 50 ug human placental tissue lysate
Lane2: 40 ug human placental tissue lysate
Lane3: 30 ug human placental tissue lysate
Lane4: 20 ug human placental tissue lysate
Lane5: 20 ug human myometrial tissue lysate
Primary Antibody Dilution:
Goat anti-rabbit HRP
Secondary Antibody Dilution:
Hiten Mistry, Ania Czajka and Marta Hentschke Ribeiro, King's College London
|Human placental ||Sample Type :|
Human placental tissue Primary Antibody Dilution :
1:50Secondary Antibody :
Goat anti rabbit-HRP Secondary Antibody Dilution :
1:10,000Color/Signal Descriptions :
Purple: HaemotoxylinGene Name :
CAV2Submitted by :
Dr. Hiten D. Mistry and Anna Czajka, King's College London; Lesia Kurlak, University of Nottingham