| Product Number |
AVARP09014_P050 |
| Product Page |
www.avivasysbio.com/hspd1-antibody-c-terminal-region-avarp09014-p050.html |
| Name |
HSPD1 Antibody - C-terminal region (AVARP09014_P050) |
| Protein Size (# AA) |
573 amino acids |
| Molecular Weight |
61kDa |
| NCBI Gene Id |
3329 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Heat shock 60kDa protein 1 (chaperonin) |
| Description |
|
| Alias Symbols |
HLD4, CPN60, GROEL, HSP60, HSP65, SPG13, HSP-60, HuCHA60 |
| Peptide Sequence |
Synthetic peptide located within the following region: PTKVVRTALLDAAGVASLLTTAEVVVTEIPKEEKDPGMGAMGGMGGGMGG |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Hewamadduma,C.A., (2008) Neurology 70 (19), 1717-1718 |
| Description of Target |
HSPD1 is a member of the chaperonin family. This mitochondrial protein may function as a signaling molecule in the innate immune system. It is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Two pseudogenes, both located on chromosome 8, have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. |
| Protein Interactions |
RGS20; NOTCH2NL; KRTAP10-3; KRTAP10-8; SAMD3; KRT40; LZTS2; CEP70; HUWE1; TMCC2; KRT31; KRTAP5-9; FUS; TUBGCP3; AURKB; VCP; UBC; TUBG1; AURKA; SUMO3; LGALS3BP; CDC20; STAU1; LGR4; NEDD8; MDM2; ERG; ASB4; EED; MAPK14; ATP6V1A; RAB1B; C12orf10; NAGK; C11orf |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-HSPD1 (AVARP09014_P050) antibody |
| Blocking Peptide |
For anti-HSPD1 (AVARP09014_P050) antibody is Catalog # AAP30181 (Previous Catalog # AAPS08909) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human HSPD1 |
| Uniprot ID |
P10809 |
| Protein Name |
60 kDa heat shock protein, mitochondrial |
| Publications |
Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells. Sci Rep. 9, 14746 (2019). 31611601 |
| Protein Accession # |
NP_002147 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_002156 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
HSPD1 |
| Predicted Species Reactivity |
Human, Rat, Guinea Pig, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Guinea Pig: 90%; Human: 84%; Rabbit: 84%; Rat: 84% |
| Image 1 | Human Liver
 | WB Suggested Anti-HSPD1 Antibody Titration: 0.2-1 ug/ml
Positive Control: Human Liver |
|
| Image 2 | Human fibroblast mitochondria
 | Lanes:
Lane1: 40ug human fibroblast mitochondria
Primary Antibody Dilution:
1:1000
Secondary Antibody:
Anti-Rabbit HRP
Secondary Antibody Dilution:
1:5000
Gene Name:
HSPD1
Submitted by:
Oleh Khalimonchuk, University of Nebraska-Lincoln
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