Product Number |
AVARP09001_P050 |
Product Page |
www.avivasysbio.com/dok1-antibody-c-terminal-region-avarp09001-p050.html |
Name |
DOK1 Antibody - C-terminal region (AVARP09001_P050) |
Protein Size (# AA) |
481 amino acids |
Molecular Weight |
53kDa |
NCBI Gene Id |
1796 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
Alias Symbols |
pp62, P62DOK |
Peptide Sequence |
Synthetic peptide located within the following region: EPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Zhao,M., (2006) Mol. Cell. Biol. 26 (7), 2479-2489. Sanjuan,J., et al., (2006) Psychiatr. Genet. 16 (2), 67-72. |
Description of Target |
DOK1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. DOK1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling.Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. |
Protein Interactions |
UBC; RASA1; ABL1; CD28; Nck1; Syngap1; INSR; CRKL; BCR; Dlg4; gag-pol; ERBB2; VAV1; SRC; SHC1; PTK6; PIK3R1; ITK; FGR; CRK; ABL2; CBLL1; INPP5D; NCK2; MAP4K4; PTPRH; GRB10; TEC; ITGB2; SH2D1A; FES; PTPN6; ITGB3; PLCG1; LYN; KIT; YES1; RET; LCK; ITGB5; ITG |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-DOK1 (AVARP09001_P050) antibody |
Blocking Peptide |
For anti-DOK1 (AVARP09001_P050) antibody is Catalog # AAP30173 |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human DOK1 |
Uniprot ID |
Q99704 |
Protein Name |
Docking protein 1 |
Protein Accession # |
NP_001372 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_001381 |
Tested Species Reactivity |
Human |
Gene Symbol |
DOK1 |
Predicted Species Reactivity |
Human, Horse |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Horse: 84%; Human: 100% |
Image 1 | Human 293T
| WB Suggested Anti-DOK1 Antibody Titration: 0.2-1 ug/ml Positive Control: Transfected 293T |
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