MAPK14 Antibody - C-terminal region (AVARP06004_T100)

• Product Number: AVARP06004_T100
• Name: MAPK14 Antibody - C-terminal region (AVARP06004_T100)
• Protein Size (# AA): 360 amino acids
• Molecular Weight: 41kDa
• NCBI Gene Id: 1432
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 1.0 mg/ml
• Gene Full Name: Mitogen-activated protein kinase 14
• Alias Symbols: RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA
• Peptide Sequence: Synthetic peptide located within the following region: YHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Choi,S.Y., et al., (2006) J. Biol. Chem. 281 (11), 7049-7059
• Description of Target: MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
• Protein Interactions: MAPKAPK2; ATF2; PDX1; UBC; MARCKSL1; MAP2K3; MAPK14; ATF6; TCEAL1; USP11; PTPN11; OXCT1; NME1; WDR1; HSPD1; TYMS; ADSS; IQGAP1; MKNK1; MAPKAPK3; CNBP; AKT1; CCDC8; OBSL1; RRP1B; RPS6KA4; SRPK1; MAP2K6; MAPK11; NEB; MAZ; MKNK2; EEF2; DUSP9; ZFP36L1; ADRB2;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-MAPK14 (AVARP06004_T100) antibody is Catalog # AAP30459
• Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human MAPK14
• Uniprot ID: Q16539
• Protein Name: Mitogen-activated protein kinase 14
• Sample Type Confirmation:

  MAPK14 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

• Protein Accession #: NP_001306
• Purification: Protein A purified
• Nucleotide Accession #: NM_001315
• Tested Species Reactivity: Human
• Gene Symbol: MAPK14
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Horse, Pig, Rabbit, Sheep
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%
• Image 1: Human Jurkat Whole Cell
  
  Host: Rabbit
  Target Name: MAPK14
  Sample Tissue: Human Jurkat Whole Cell
  Antibody Dilution: 1ug/ml
• Image 2: Human Jurkat
  
  WB Suggested Anti-MAPK14 Antibody
  Titration: 0.625 ug/ml
  Positive Control: Jurkat Whole CellMAPK14 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells