| Product Number |
AVARP04011_P050 |
| Product Page |
www.avivasysbio.com/fos-antibody-n-terminal-region-avarp04011-p050.html |
| Name |
FOS Antibody - N-terminal region (AVARP04011_P050) |
| Protein Size (# AA) |
380 amino acids |
| Molecular Weight |
41kDa |
| NCBI Gene Id |
2353 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
FBJ murine osteosarcoma viral oncogene homolog |
| Alias Symbols |
p55, AP-1, C-FOS |
| Peptide Sequence |
Synthetic peptide located within the following region: MFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCT |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Seldeen,K.L., (2008) Arch. Biochem. Biophys. 473 (1), 48-60 |
| Description of Target |
The Fos family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. The family members are leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death.The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
Psma4; CENPO; LMO3; ARFGAP1; USF2; USF1; PSMC5; PRKAA2; JUNB; JUN; GNG11; NQO1; ATF2; AQP1; LUZP4; CYTH4; CREB5; ABL1; CLU; ATP5I; APP; MTERF4; ANP32E; ARL6IP4; COPS4; CABP1; ZNF133; SET; NEFM; MAP1B; JUND; HSPA1A; MAF; FOS; DDIT3; CEBPG; CEBPE; CEBPA; AT |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Enhanced Validation |
| Relative Expression (Western Blot) |
 |
|
| Datasheets/Manuals |
Printable datasheet for anti-FOS (AVARP04011_P050) antibody |
| Blocking Peptide |
For anti-FOS (AVARP04011_P050) antibody is Catalog # AAP30253 (Previous Catalog # AAPP01194) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human FOS |
| Uniprot ID |
P01100 |
| Protein Name |
Proto-oncogene c-Fos |
| Protein Accession # |
NP_005243 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_005252 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
FOS |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Pig, Sheep |
| Application |
WB, IHC |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Sheep: 100% |
| Image 1 | Human liver tissue
 | Rabbit Anti-FOS Antibody
Catalog Number: AVARP04011_P050
Formalin Fixed Paraffin Embedded Tissue: Human Liver Tissue
Observed Staining: Nucleus in hepatocytes
Primary Antibody Concentration: 1:100
Other Working Concentrations: 1:600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec |
|
| Image 2 | Human PANC1 Whole Cell
 | Host: Rabbit
Target Name: FOS
Sample Tissue: Human PANC1 Whole Cell
Antibody Dilution: 1ug/ml |
|
| Image 3 |
 | 25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 1 ug/mL of the antibody was used in this experiment. The protein may be modified by glycosylation and phosphorylation.
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