Product Number |
AVARP03047_P050 |
Product Page |
www.avivasysbio.com/cdkn2b-antibody-middle-region-avarp03047-p050.html |
Name |
CDKN2B Antibody - middle region (AVARP03047_P050) |
Protein Size (# AA) |
138 amino acids |
Molecular Weight |
15kDa |
NCBI Gene Id |
1030 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) |
Alias Symbols |
P15, MTS2, TP15, CDK4I, INK4B, p15INK4b |
Peptide Sequence |
Synthetic peptide located within the following region: REGFLDTLVVLHRAGARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Scott,S.A., et al., (2004) Leuk. Res. 28 (12), 1293-1301 |
Description of Target |
CDKN2B's gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. CDKN2B is a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. |
Protein Interactions |
UBC; TRAF1; CDK6; CCDC33; NIF3L1; CDK4; PYCRL; RNF20; TGFB1I1; ISL1; APP; KIAA1377; CCDC90B; ARPC3; ZBTB17; IKBKAP; CDK8; MAGEA11; PIAS2; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-CDKN2B (AVARP03047_P050) antibody |
Blocking Peptide |
For anti-CDKN2B (AVARP03047_P050) antibody is Catalog # AAP30194 (Previous Catalog # AAPP00351) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human CDKN2B |
Uniprot ID |
P42772 |
Protein Name |
Cyclin-dependent kinase 4 inhibitor B |
Protein Accession # |
NP_004927 |
Nucleotide Accession # |
NM_004936 |
Tested Species Reactivity |
Human |
Gene Symbol |
CDKN2B |
Predicted Species Reactivity |
Human, Mouse, Rat, Dog, Guinea Pig, Pig, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Dog: 91%; Guinea Pig: 83%; Mouse: 83%; Pig: 100%; Rabbit: 91%; Rat: 83% |
Image 1 | Human Lung Tumor
| Host: Rabbit Target Name: CDKN2B Sample Tissue: Human Lung Tumor Antibody Dilution: 1ug/ml |
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Image 2 | Human Jurkat
| WB Suggested Anti-CDKN2B Antibody Titration: 0.2-1 ug/ml Positive Control: Jurkat cell lysate |
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