Product Number |
AVARP03042_T100-FITC |
Product Page |
www.avivasysbio.com/rbx1-antibody-middle-region-fitc-avarp03042-t100-fitc.html |
Name |
RBX1 Antibody - middle region : FITC (AVARP03042_T100-FITC) |
Protein Size (# AA) |
108 amino acids |
Molecular Weight |
12kDa |
Conjugation |
FITC: Fluorescein Isothiocyanate |
NCBI Gene Id |
9978 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Ring-box 1, E3 ubiquitin protein ligase |
Alias Symbols |
ROC1, RNF75, BA554C12.1 |
Peptide Sequence |
Synthetic peptide located within the following region: NQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer. |
Reference |
Zheng, N., et al., (2002) Nature 416 (6882), 703-709. |
Description of Target |
ROC1 encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over. |
Protein Interactions |
CDT1; CDC34; KEAP1; UBE2L6; UBE2M; CUL1; CUL3; CUL4B; UBE2D3; UBE2D2; UBE2D1; DAB2IP; UBC; TP53; PRAME; DCUN1D1; CUL2; DCUN1D3; MAP4K1; VHL; NEDD4; MTSS1; VRK2; HIST1H4A; GFPT1; CTNNB1; CCNE1; DCUN1D5; FBXL5; RHOBTB3; SAMHD1; UBC12; FBXL15; UBE2R2; SERTAD |
Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
Datasheets/Manuals |
Printable datasheet for anti-RBX1 (AVARP03042_T100-FITC) antibody |
Blocking Peptide |
For anti-RBX1 (AVARP03042_T100-FITC) antibody is Catalog # AAP30461 (Previous Catalog # AAPP01045) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human RBX1 |
Uniprot ID |
P62877 |
Publications |
Maerki, S. et al. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J. Cell Biol. 187, 791-800 (2009). WB, Bovine, Dog, Guinea pig, Human, Mouse, Rat, Zebrafish 19995937 |
Protein Accession # |
NP_055063 |
Nucleotide Accession # |
NM_014248 |
Gene Symbol |
RBX1 |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Guinea Pig, Zebrafish |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100% |
Image 1 | |