RBX1 Antibody - middle region : FITC (AVARP03042_T100-FITC)

Data Sheet
 
Product Number AVARP03042_T100-FITC
Product Page www.avivasysbio.com/rbx1-antibody-middle-region-fitc-avarp03042-t100-fitc.html
Name RBX1 Antibody - middle region : FITC (AVARP03042_T100-FITC)
Protein Size (# AA) 108 amino acids
Molecular Weight 12kDa
Conjugation FITC: Fluorescein Isothiocyanate
NCBI Gene Id 9978
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Ring-box 1, E3 ubiquitin protein ligase
Alias Symbols ROC1, RNF75, BA554C12.1
Peptide Sequence Synthetic peptide located within the following region: NQASATSEECTVAWGVCNHAFHFHCISRWLKTRQVCPLDNREWEFQKYGH
Product Format Liquid. Purified antibody supplied in 1x PBS buffer.
Reference Zheng, N., et al., (2002) Nature 416 (6882), 703-709.
Description of Target ROC1 encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over.
Protein Interactions CDT1; CDC34; KEAP1; UBE2L6; UBE2M; CUL1; CUL3; CUL4B; UBE2D3; UBE2D2; UBE2D1; DAB2IP; UBC; TP53; PRAME; DCUN1D1; CUL2; DCUN1D3; MAP4K1; VHL; NEDD4; MTSS1; VRK2; HIST1H4A; GFPT1; CTNNB1; CCNE1; DCUN1D5; FBXL5; RHOBTB3; SAMHD1; UBC12; FBXL15; UBE2R2; SERTAD
Reconstitution and Storage All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Datasheets/Manuals Printable datasheet for anti-RBX1 (AVARP03042_T100-FITC) antibody
Blocking Peptide For anti-RBX1 (AVARP03042_T100-FITC) antibody is Catalog # AAP30461 (Previous Catalog # AAPP01045)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human RBX1
Uniprot ID P62877
Publications

Maerki, S. et al. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J. Cell Biol. 187, 791-800 (2009). WB, Bovine, Dog, Guinea pig, Human, Mouse, Rat, Zebrafish 19995937

Protein Accession # NP_055063
Nucleotide Accession # NM_014248
Gene Symbol RBX1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100%
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