| Product Number |
AVARP03040_P050 |
| Product Page |
www.avivasysbio.com/cdc25a-antibody-middle-region-avarp03040-p050.html |
| Name |
CDC25A Antibody - middle region (AVARP03040_P050) |
| Protein Size (# AA) |
484 amino acids |
| Molecular Weight |
54kDa |
| NCBI Gene Id |
993 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Cell division cycle 25 homolog A (S. pombe) |
| Alias Symbols |
CDC25A2 |
| Peptide Sequence |
Synthetic peptide located within the following region: MELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Ray,D. (2008) Cancer Res. 68 (5), 1251-1253 |
| Description of Target |
CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. |
| Protein Interactions |
ANAPC11; FZR1; FBXW11; BTRC; CUL1; SKP1; VCP; UBC; NPLOC4; YWHAQ; SCYL1; CAMK1D; POLR1D; FGF21; CHEK2; CCNI; MCM3AP; VAMP8; CUL3; XPO1; SOX5; PEX19; NFYA; NFKBIB; MTAP; SMAD3; LMO2; IL3RA; HLA-C; FTH1; EEF1A1; DMD; CHEK1; APP; TRIB3; CSNK1A1; CDK2; FAM193 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CDC25A (AVARP03040_P050) antibody |
| Blocking Peptide |
For anti-CDC25A (AVARP03040_P050) antibody is Catalog # AAP30148 (Previous Catalog # AAPP00305) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human CDC25A |
| Uniprot ID |
P30304 |
| Protein Name |
M-phase inducer phosphatase 1 |
| Protein Accession # |
NP_963861 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_201567 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CDC25A |
| Predicted Species Reactivity |
Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Dog: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100% |
| Image 1 | Human Brain
 | WB Suggested Anti-CDC25A Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Human brain |
|
