CCND1 Antibody - middle region (AVARP03037_P050)

Data Sheet
 
Product Number AVARP03037_P050
Product Page www.avivasysbio.com/ccnd1-antibody-middle-region-avarp03037-p050.html
Name CCND1 Antibody - middle region (AVARP03037_P050)
Protein Size (# AA) 295 amino acids
Molecular Weight 34kDa
NCBI Gene Id 595
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Cyclin D1
Alias Symbols BCL1, PRAD1, U21B31, D11S287E
Peptide Sequence Synthetic peptide located within the following region: ACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Kibel,A.S., (2008) Prostate 68 (11), 1179-1186
Description of Target CCND1 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Interactions CDKN1B; CDKN1A; CDK4; RELA; FBXO31; UBC; FBXO4; CAMK1; TP73; RB1; CDK2; HSPA8; POLR1B; MCM10; ORC4; LPL; BRINP1; CDK6; RABEP1; CARD11; CUL1; RBL2; UBTF; CCND1; ATF2; CDKN2A; FBXW8; BTRC; PPP1CC; PPP1CB; PSMA6; ITLN1; MCM7; MCM6; MCM3; MCM2; ELAVL1; PCNA;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-CCND1 (AVARP03037_P050) antibody
Blocking Peptide For anti-CCND1 (AVARP03037_P050) antibody is Catalog # AAP30439 (Previous Catalog # AAPP01023)
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human CCND1
Uniprot ID P24385
Protein Name G1/S-specific cyclin-D1
Protein Accession # NP_444284
Purification Affinity Purified
Nucleotide Accession # NM_053056
Tested Species Reactivity Human
Gene Symbol CCND1
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 90%; Dog: 90%; Guinea Pig: 100%; Horse: 90%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 81%
Image 1
Human 721_B
WB Suggested Anti-CCND1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 721_B cell lysate
 

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