Product Number |
AVARP03034_P050 |
Product Page |
www.avivasysbio.com/cdc25c-antibody-n-terminal-region-avarp03034-p050.html |
Name |
CDC25C Antibody - N-terminal region (AVARP03034_P050) |
Protein Size (# AA) |
400 amino acids |
Molecular Weight |
45kDa |
NCBI Gene Id |
995 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Cell division cycle 25 homolog C (S. pombe) |
Alias Symbols |
CDC25, PPP1R60 |
Peptide Sequence |
Synthetic peptide located within the following region: QKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALRE |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Bonnet,J., (2008) Biochem. Biophys. Res. Commun. 370 (3), 483-488 |
Description of Target |
CDC25C gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. |
Protein Interactions |
CDC37; UBC; HSP90AA1; HSPA4; YWHAB; YWHAQ; YWHAZ; YWHAH; YWHAG; YWHAE; PKN1; SFN; MAPK9; PLK1; CHEK1; CHEK2; CDS1; MARK3; BRSK2; CDK2; PCNA; Cdk1; USP17L2; MAPK3; MAPK1; BRSK1; LZTS1; PLK3; NEDD4; PIN1; MAPK14; TP53; HRAS; LCK; CCNB1; CCNA2; SRC; SP1; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-CDC25C (AVARP03034_P050) antibody |
Blocking Peptide |
For anti-CDC25C (AVARP03034_P050) antibody is Catalog # AAP30150 (Previous Catalog # AAPP00307) |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CDC25C |
Uniprot ID |
P30307 |
Protein Name |
M-phase inducer phosphatase 3 |
Sample Type Confirmation |
There is BioGPS gene expression data showing that CDC25C is expressed in Jurkat |
Protein Accession # |
NP_073720 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_022809 |
Tested Species Reactivity |
Human |
Gene Symbol |
CDC25C |
Predicted Species Reactivity |
Human, Mouse, Rabbit |
Application |
WB |
Predicted Homology Based on Immunogen Sequence |
Human: 100%; Mouse: 91%; Rabbit: 83% |
Image 1 | Human Jurkat
| WB Suggested Anti-CDC25C Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: Jurkat cell lysateThere is BioGPS gene expression data showing that CDC25C is expressed in Jurkat |
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