| Product Number |
AVARP03026_T100 |
| Product Page |
www.avivasysbio.com/ccnh-antibody-c-terminal-region-avarp03026-t100.html |
| Name |
CCNH Antibody - C-terminal region (AVARP03026_T100) |
| Protein Size (# AA) |
323 amino acids |
| Molecular Weight |
38 kDa |
| NCBI Gene Id |
902 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Cyclin H |
| Alias Symbols |
CAK, p34, p37, CycH |
| Peptide Sequence |
Synthetic peptide located within the following region: KQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Maekelae, T.P., et al., (1994) Nature 371:254-257. |
| Description of Target |
Cyclin H regulates CDK7, the catalytic subunit of the CDK- activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDC2/CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive carboxyl-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. It is involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. |
| Protein Interactions |
SFN; GOLGA2; SSX2IP; CCDC170; CCDC33; DUSP12; SSSCA1; NDC80; CALCOCO2; PPFIA1; PSMA1; KLC3; RPA3; RPA2; RPA1; NEDD4; CDK7; CDK8; CDK2; CCNC; MNAT1; MBP; CTD; CDK20; CTBP2; CSNK2B; TRIM8; GANAB; RARB; POLR2A; GTF2H4; ERCC2; tat; POLR2B; CDK9; BRCA1; GTF2H1 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CCNH (AVARP03026_T100) antibody |
| Blocking Peptide |
For anti-CCNH (AVARP03026_T100) antibody is Catalog # AAP30171 (Previous Catalog # AAPP00328) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of human CCNH |
| Uniprot ID |
P51946 |
| Protein Name |
Cyclin-H |
| Sample Type Confirmation |
CCNH is supported by BioGPS gene expression data to be expressed in Jurkat |
| Protein Accession # |
NP_001230 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_001239 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CCNH |
| Predicted Species Reactivity |
Human, Mouse, Rat, Guinea Pig, Horse, Rabbit |
| Application |
IHC, WB |
| Predicted Homology Based on Immunogen Sequence |
Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 83%; Rabbit: 83%; Rat: 83% |
| Image 1 | Human Lung
 | Human Lung |
| | Image 2 |
 | 25 ug of the indicated Human whole cell extracts was loaded onto a 12% SDS-PAGE gel. 5 ug/mL of the antibody was used in this experiment.
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