| Product Number |
AVARP03004_T100 |
| Product Page |
www.avivasysbio.com/cdk9-antibody-n-terminal-region-avarp03004-t100.html |
| Name |
CDK9 Antibody - N-terminal region (AVARP03004_T100) |
| Protein Size (# AA) |
372 amino acids |
| Molecular Weight |
43kDa |
| NCBI Gene Id |
1025 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
Cyclin-dependent kinase 9 |
| Alias Symbols |
TAK, C-2k, CTK1, CDC2L4, PITALRE |
| Peptide Sequence |
Synthetic peptide located within the following region: PFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFP |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Li,Q., (2005) J. Biol. Chem. 280 (31), 28819-28826 |
| Description of Target |
CDK9 is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. |
| Protein Interactions |
UBC; MEPCE; tat; LARP7; BRD4; CCNT1; ATM; SUMO2; AFF1; HEXIM1; FKBP5; RNF20; MSL2; RNF40; HIST2H2BE; POLR2A; MSL1; CDK9; SMC2; PLEC; CCAR2; SMC4; STIP1; MLLT3; MLLT1; CDK12; AFF4; FGFR1; CCNT2; AFF3; FBXO25; CUL1; SKIV2L; ATP1A1; SUPT5H; RPS4X; RN7SK; HEX |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CDK9 (AVARP03004_T100) antibody |
| Blocking Peptide |
For anti-CDK9 (AVARP03004_T100) antibody is Catalog # AAP30157 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CDK9 |
| Uniprot ID |
P50750 |
| Protein Name |
Cyclin-dependent kinase 9 |
| Protein Accession # |
NP_001252 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_001261 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CDK9 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Pig, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 92%; Dog: 100%; Human: 100%; Mouse: 92%; Pig: 92%; Rat: 92%; Zebrafish: 92% |
| Image 1 | Human 293T
 | WB Suggested Anti-CDK9 Antibody
Titration: 2.5 ug/ml
Positive Control: Transfected 293T |
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