RIPK2 Antibody - middle region (AVARP02047_P050)

• Product Number: AVARP02047_P050
• Name: RIPK2 Antibody - middle region (AVARP02047_P050)
• Protein Size (# AA): 540 amino acids
• Molecular Weight: 61kDa
• NCBI Gene Id: 8767
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Receptor-interacting serine-threonine kinase 2
• Alias Symbols: CCK, RICK, RIP2, CARD3, GIG30, CARDIAK
• Peptide Sequence: Synthetic peptide located within the following region: LRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Hasegawa,M., (2008) EMBO J. 27 (2), 373-383
• Description of Target: RIPK2 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. It contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Protein Interactions: RIPK2; XIAP; UBC; TRAF3; KDM3A; PRMT2; PELI3; NOD1; MAP3K7; CHUK; LRRK2; NOD2; TRAF4; TRAF6; MAP3K4; CASP12; NAT16; RNF31; RIPK1; MAVS; TRAF2; TAB2; TAB1; IKBKG; BIRC3; BIRC2; CARD16; CARD6; UBE2I; SMURF1; CFLAR; BCL10; TLR4; TLR2; TRAF5; CASP8; TRAF1; SM
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-RIPK2 (AVARP02047_P050) antibody is Catalog # AAP30513 (Previous Catalog # AAPP01149)
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human RIPK2
• Uniprot ID: O43353
• Protein Name: Receptor-interacting serine/threonine-protein kinase 2
• Protein Accession #: NP_003812
• Purification: Affinity Purified
• Nucleotide Accession #: NM_003821
• Tested Species Reactivity: Human, Rat
• Gene Symbol: RIPK2
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
• Application: IF, WB
• Predicted Homology Based on Immunogen Sequence: Cow: 85%; Dog: 85%; Guinea Pig: 78%; Horse: 85%; Human: 85%; Mouse: 78%; Rabbit: 84%; Rat: 78%
• Image 1: Rat thyrocytes-FRTL-5
  
  Sample Type:
  Rat thyrocytes-FRTL-5
  Primary Antibody Dilution:
  1:100
  Secondary Antibody:
  Anti-rabbit-Texas Red
  Secondary Antibody Dilution:
  1:100
  Color/Signal Descriptions:
  Red: RIPK2 Blue: DAPI
  Gene Name:
  RIPK2
  Submitted by:
  Syed A Morshed, Mount Sinai School of Medicine and James J Peters VA Medical Center
• Image 2: Human HepG2
  
  WB Suggested Anti-RIPK2 Antibody Titration: 0.2-1 ug/ml
  ELISA Titer: 1:312500
  Positive Control: HepG2 cell lysate