TNFSF10 Antibody - N-terminal region (AVARP02040_P050)

• Product Number: AVARP02040_P050
• Name: TNFSF10 Antibody - N-terminal region (AVARP02040_P050)
• Protein Size (# AA): 281 amino acids
• Molecular Weight: 33kDa
• NCBI Gene Id: 8743
• Host: Rabbit
• Clonality: Polyclonal
• Concentration: 0.5 mg/ml
• Gene Full Name: Tumor necrosis factor (ligand) superfamily, member 10
• Alias Symbols: TL2, APO2L, CD253, TRAIL, Apo-2L, TNLG6A
• Peptide Sequence: Synthetic peptide located within the following region: CFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQE
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Reference: Wu,Y.Y., et al., (2004) World J. Gastroenterol. 10 (16), 2334-2339
• Description of Target: TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
• Protein Interactions: CASP8; CASP3; CFLAR; TNFRSF10B; FADD; RIPK1; TRAF2; TNFAIP3; SOCS3; RBM48; TNFRSF10D; TNFRSF10C; TNFRSF10A; TNFSF10; TNFRSF11B; ACP5; IER3; CREBBP; SP3; SP1; HDAC5; HDAC4; HDAC3; HDAC2; HDAC1; HIST3H3;
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Blocking Peptide: For anti-TNFSF10 (AVARP02040_P050) antibody is Catalog # AAP30629 (Previous Catalog # AAPP01282)
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TNFSF10
• Uniprot ID: P50591
• Protein Name: Tumor necrosis factor ligand superfamily member 10
• Publications:

  Ceballos, M. P. et al. FoxO3a Nuclear Localization and Its Association with beta-Catenin and Smads in IFN-a-Treated Hepatocellular Carcinoma Cell Lines. J. Interferon Cytokine Res. doi:10.1089/jir.2013.0124 (2014). 24950290

• Protein Accession #: NP_003801
• Purification: Affinity Purified
• Nucleotide Accession #: NM_003810
• Tested Species Reactivity: Human
• Gene Symbol: TNFSF10
• Predicted Species Reactivity: Human, Dog, Pig
• Application: WB
• Predicted Homology Based on Immunogen Sequence: Dog: 80%; Human: 100%; Pig: 78%
• Image 1: Human HeLa
  
  WB Suggested Anti-TNFSF10 Antibody Titration: 0.2-1 ug/ml
  Positive Control: Hela cell lysate