| Product Number |
AVARP02011_P050 |
| Product Page |
https://www.avivasysbio.com/cflar-antibody-c-terminal-region-avarp02011-p050.html |
| Name |
CFLAR Antibody - C-terminal region (AVARP02011_P050) |
| Protein Size (# AA) |
480 amino acids |
| Molecular Weight |
55kDa |
| NCBI Gene Id |
8837 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
CASP8 and FADD-like apoptosis regulator |
| Alias Symbols |
CASH, FLIP, MRIT, CLARP, FLAME, cFLIP, Casper, FLAME1, c-FLIP, FLAME-1, I-FLICE, c-FLIPL, c-FLIPR, c-FLIPS, CASP8AP1 |
| Peptide Sequence |
Synthetic peptide located within the following region: LRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Geserick,P., (2008) Oncogene 27 (22), 3211-3220 |
| Description of Target |
CFLAR belongs to the peptidase C14A family. It is a apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. The protein acts as an inhibitor of TNFRSF6 mediated apoptosis. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. CFLAR lacks enzymatic (caspase) activity. |
| Protein Interactions |
FADD; TRAF1; GSN; SPATS1; TNFSF10; RIPK1; RAF1; SMAD3; CASP8; HSP90AA1; STUB1; TNFRSF10A; TNFRSF10B; UBC; FASLG; ITCH; DAXX; CBLB; ATG3; XRCC6; Mib1; TP53; DEDD2; DEDD; RIPK2; IKBKB; MAP2K7; TRAF2; CASP10; CASP7; CASP6; MAP2K4; PSEN2; CASP2; CASP3; BCL2L1 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CFLAR (AVARP02011_P050) antibody |
| Blocking Peptide |
For anti-CFLAR (AVARP02011_P050) antibody is Catalog # AAP30267 (Previous Catalog # AAPP00437) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the C-terminal region of human CFLAR |
| Uniprot ID |
O15519 |
| Protein Name |
CASP8 and FADD-like apoptosis regulator |
| Sample Type Confirmation |
CFLAR is strongly supported by BioGPS gene expression data to be expressed in 721_B |
| Protein Accession # |
NP_003870 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_003879 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CFLAR |
| Predicted Species Reactivity |
Human |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Human: 100% |
| Image 1 | Human 721_B
 | WB Suggested Anti-CFLAR Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:2500
Positive Control: 721_B cell lysateCFLAR is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells |
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