| Product Number |
AVARP01018_P050 |
| Product Page |
www.avivasysbio.com/foxo4-antibody-middle-region-avarp01018-p050.html |
| Name |
FOXO4 Antibody - middle region (AVARP01018_P050) |
| Protein Size (# AA) |
505 amino acids |
| Molecular Weight |
54kDa |
| NCBI Gene Id |
4303 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
Forkhead box O4 |
| Alias Symbols |
AFX, AFX1, MLLT7 |
| Peptide Sequence |
Synthetic peptide located within the following region: YLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPI |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Boura,E., (2007) J. Biol. Chem. 282 (11), 8265-8275 |
| Description of Target |
FOXO4 is transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. The protein can down-regulate expression of HIF1A and suppress hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle. A chromosomal aberration involving FOXO4 is found in acute leukemias. |
| Protein Interactions |
REL; SFN; AKT1; OGT; UBC; ATXN3; MDM2; NLK; USP7; CTNNB1; CREBBP; VDR; SIRT1; SMAD3; XPO1; YWHAZ; SMAD4; FOXG1; AKT2; ESR1; PIN1; CCND1; CDKN1A; |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-FOXO4 (AVARP01018_P050) antibody |
| Blocking Peptide |
For anti-FOXO4 (AVARP01018_P050) antibody is Catalog # AAP30320 (Previous Catalog # AAPP00701) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human FOXO4 |
| Uniprot ID |
P98177 |
| Protein Name |
Forkhead box protein O4 |
| Protein Accession # |
NP_005929 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_005938 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
FOXO4 |
| Predicted Species Reactivity |
Human, Mouse, Rat, Dog, Horse, Pig |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100% |
| Image 1 | Human 293T
 | WB Suggested Anti-FOXO4 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:2500
Positive Control: 293T cell lysate |
|
|
