CDC42 Antibody - N-terminal region : FITC (AVARP01017_P050-FITC)

Data Sheet
 
Product Number AVARP01017_P050-FITC
Product Page www.avivasysbio.com/cdc42-antibody-n-terminal-region-fitc-avarp01017-p050-fitc.html
Name CDC42 Antibody - N-terminal region : FITC (AVARP01017_P050-FITC)
Protein Size (# AA) 191 amino acids
Molecular Weight 21kDa
Conjugation FITC: Fluorescein Isothiocyanate
NCBI Gene Id 998
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name Cell division cycle 42 (GTP binding protein, 25kDa)
Alias Symbols TKS, G25K, CDC42Hs
Peptide Sequence Synthetic peptide located within the following region: DNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSP
Product Format Liquid. Purified antibody supplied in 1x PBS buffer.
Reference Black,S.A. (2008) J. Biol. Chem. 283 (16), 10835-10847
Description of Target CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.
Protein Interactions PARD6B; CDC42EP1; CDC42EP2; PAK2; UBC; TRAF2; PAK1; ARHGDIA; BIRC2; TNK2; TCEB2; EPRS; LARS; RUVBL1; NEK6; WIPF1; WASL; RIOK3; SSX2IP; DIAPH3; BAIAP2; PAK3; ZNF420; IQGAP1; RAP1A; WAS; TGFBR2; TGFBR1; ARHGEF6; LRRK2; FGD3; ARHGAP1; SH3RF3; BCAR1; USP6; EL
Reconstitution and Storage All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Datasheets/Manuals Printable datasheet for anti-CDC42 (AVARP01017_P050-FITC) antibody
Blocking Peptide For anti-CDC42 (AVARP01017_P050-FITC) antibody is Catalog # AAP30406 (Previous Catalog # AAPP00929)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human CDC42
Uniprot ID P60953
Protein Name Cell division control protein 42 homolog
Sample Type Confirmation

CDC42 is supported by BioGPS gene expression data to be expressed in 721_B

Protein Accession # NP_001782
Nucleotide Accession # NM_001791
Gene Symbol CDC42
Predicted Species Reactivity Dog, Rabbit
Application WB, IHC
Predicted Homology Based on Immunogen Sequence Dog: 100%; Rabbit: 100%
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