CSE1L Antibody - N-terminal region (AVARP00023_P050)

Data Sheet
 
Product Number AVARP00023_P050
Product Page www.avivasysbio.com/cse1l-antibody-n-terminal-region-avarp00023-p050.html
Name CSE1L Antibody - N-terminal region (AVARP00023_P050)
Protein Size (# AA) 971 amino acids
Molecular Weight 110kDa
NCBI Gene Id 1434
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name CSE1 chromosome segregation 1-like (yeast)
Alias Symbols CAS, CSE1, XPO2
Peptide Sequence Synthetic peptide located within the following region: ELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLE
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reference Kim,H.E., (2008) Mol. Cell 30 (2), 239-247
Description of Target Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the protein may play a role both in apoptosis and in cell proliferation.Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Protein Interactions ERLIN2; HUWE1; UBC; FUS; SUMO2; STAU1; SUMO1; NEDD8; ASB16; RNF2; SUZ12; PDIA3; TBCB; CKB; GINS3; BCCIP; UBFD1; CNDP2; SCLY; CHORDC1; RRAGB; GDA; NPEPPS; SLC9A3R1; KYNU; TGM2; TCEA1; SMS; RPS6KA3; MVD; LDHA; FBXO6; YWHAQ; EGFR; UBD; PTMA; CLN3; HDAC6; MMS
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-CSE1L (AVARP00023_P050) antibody
Blocking Peptide For anti-CSE1L (AVARP00023_P050) antibody is Catalog # AAP30496 (Previous Catalog # AAPP01132)
Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human CSE1L
Uniprot ID P55060
Protein Name Exportin-2
Protein Accession # NP_001307
Purification Affinity Purified
Nucleotide Accession # NM_001316
Tested Species Reactivity Human
Gene Symbol CSE1L
Predicted Species Reactivity Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Zebrafish
Application WB
Predicted Homology Based on Immunogen Sequence Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Image 1
Human Brain
WB Suggested Anti-CSE1L Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human brain
 

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