| Product Number |
AVARP00023_P050 |
| Product Page |
www.avivasysbio.com/cse1l-antibody-n-terminal-region-avarp00023-p050.html |
| Name |
CSE1L Antibody - N-terminal region (AVARP00023_P050) |
| Protein Size (# AA) |
971 amino acids |
| Molecular Weight |
110kDa |
| NCBI Gene Id |
1434 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
CSE1 chromosome segregation 1-like (yeast) |
| Alias Symbols |
CAS, CSE1, XPO2 |
| Peptide Sequence |
Synthetic peptide located within the following region: ELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLE |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Kim,H.E., (2008) Mol. Cell 30 (2), 239-247 |
| Description of Target |
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the protein may play a role both in apoptosis and in cell proliferation.Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. |
| Protein Interactions |
ERLIN2; HUWE1; UBC; FUS; SUMO2; STAU1; SUMO1; NEDD8; ASB16; RNF2; SUZ12; PDIA3; TBCB; CKB; GINS3; BCCIP; UBFD1; CNDP2; SCLY; CHORDC1; RRAGB; GDA; NPEPPS; SLC9A3R1; KYNU; TGM2; TCEA1; SMS; RPS6KA3; MVD; LDHA; FBXO6; YWHAQ; EGFR; UBD; PTMA; CLN3; HDAC6; MMS |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CSE1L (AVARP00023_P050) antibody |
| Blocking Peptide |
For anti-CSE1L (AVARP00023_P050) antibody is Catalog # AAP30496 (Previous Catalog # AAPP01132) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CSE1L |
| Uniprot ID |
P55060 |
| Protein Name |
Exportin-2 |
| Protein Accession # |
NP_001307 |
| Purification |
Affinity Purified |
| Nucleotide Accession # |
NM_001316 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CSE1L |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Zebrafish |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% |
| Image 1 | Human Brain
 | WB Suggested Anti-CSE1L Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Human brain |
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