| Product Number |
AVARP00022_T100 |
| Product Page |
www.avivasysbio.com/cflar-antibody-n-terminal-region-avarp00022-t100.html |
| Name |
CFLAR Antibody - N-terminal region (AVARP00022_T100) |
| Protein Size (# AA) |
480 amino acids |
| Molecular Weight |
55kDa |
| NCBI Gene Id |
8837 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
1.0 mg/ml |
| Gene Full Name |
CASP8 and FADD-like apoptosis regulator |
| Alias Symbols |
CASH, FLIP, MRIT, CLARP, FLAME, cFLIP, Casper, FLAME1, c-FLIP, FLAME-1, I-FLICE, c-FLIPL, c-FLIPR, c-FLIPS, CASP8AP1 |
| Peptide Sequence |
Synthetic peptide located within the following region: HQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLA |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reference |
Kondo,G., et al., (2005) Oncol Rep. 14(5), 1215-22 |
| Description of Target |
CFLAR might contribute to the carcinogenesis and aggressiveness of endometrial carcinoma and might be a useful prognostic factor in the tumor. CFLAR is specially overexpressed in colon cancers and it might contribute to carcinogenesis of normal colonic mucosa. |
| Protein Interactions |
FADD; TRAF1; GSN; SPATS1; TNFSF10; RIPK1; RAF1; SMAD3; CASP8; HSP90AA1; STUB1; TNFRSF10A; TNFRSF10B; UBC; FASLG; ITCH; DAXX; CBLB; ATG3; XRCC6; Mib1; TP53; DEDD2; DEDD; RIPK2; IKBKB; MAP2K7; TRAF2; CASP10; CASP7; CASP6; MAP2K4; PSEN2; CASP2; CASP3; BCL2L1 |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-CFLAR (AVARP00022_T100) antibody |
| Blocking Peptide |
For anti-CFLAR (AVARP00022_T100) antibody is Catalog # AAP30495 (Previous Catalog # AAPP01131) |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human CFLAR |
| Uniprot ID |
O15519 |
| Protein Name |
CASP8 and FADD-like apoptosis regulator |
| Sample Type Confirmation |
CFLAR is strongly supported by BioGPS gene expression data to be expressed in HepG2 |
| Protein Accession # |
NP_003870 |
| Purification |
Protein A purified |
| Nucleotide Accession # |
NM_003879 |
| Tested Species Reactivity |
Human |
| Gene Symbol |
CFLAR |
| Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Horse |
| Application |
WB |
| Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 86%; Horse: 93%; Human: 100%; Mouse: 80%; Rat: 80% |
| Image 1 | Human 293T
 | Lanes:
Lane 1: 10ug hFLIPL transfected 293 lysate
Primary Antibody Dilution:
1:1000
Secondary Antibody:
Anti-rabbit HRP
Secondary Antibody Dilution:
1:2000
Gene Name:
CFLAR
Submitted by:
Dr. Tencho Tenev, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research
|
|
| Image 2 | Human HepG2
 | Host: Rabbit
Target Name: CFLAR
Sample Tissue: Human HepG2
Antibody Dilution: 1.0ug/ml |
|
