Product Number |
AVARP00004_P050 |
Product Page |
www.avivasysbio.com/igf1r-antibody-middle-region-avarp00004-p050.html |
Name |
IGF1R Antibody - middle region (AVARP00004_P050) |
Protein Size (# AA) |
1367 amino acids |
Molecular Weight |
71kDa |
NCBI Gene Id |
3480 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
Insulin-like growth factor 1 receptor |
Description |
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Alias Symbols |
IGFR, CD221, IGFIR, JTK13 |
Peptide Sequence |
Synthetic peptide located within the following region: DRHSGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reference |
Urano,T., (2008) Spine 33 (11), 1256-1261 |
Description of Target |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-140 DR007209.1 566-705 141-3559 X04434.1 136-3554 3560-4540 BC113610.1 3542-4522 4541-4921 DA486252.1 187-567 4922-5392 BX093045.1 248-718 5393-5768 CN414655.1 317-692 5769-6158 BM264223.1 185-574 6159-6580 BQ185364.1 187-608 6581-11242 AC069029.9 21278-25939 c |
Protein Interactions |
KCNIP3; UBC; ESR1; PHB2; SHC1; FBXO6; SH2B1; Slc23a3; RPL11; HSP90AA1; GRB14; FFAR2; ARRB2; AMY2A; APP; RUVBL1; GNB2L1; ARRB1; YWHAG; TP53; NEDD4; MDM2; GRB10; SUMO1; CAMP; ERBB2; EGFR; KRT27; DOK5; DOK4; WISP2; EHD1; ARHGEF12; PIK3R3; VAV3; PRKD1; SOCS2; |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-IGF1R (AVARP00004_P050) antibody |
Specificity |
Directed to the beta chain of IGF1R |
Blocking Peptide |
For anti-IGF1R (AVARP00004_P050) antibody is Catalog # AAP30448 (Previous Catalog # AAPP01032) |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human IGF1R |
Uniprot ID |
P08069 |
Protein Name |
Insulin-like growth factor 1 receptor |
Publications |
Kubota, T. et al. Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading. Acta Astronaut. 92, 73-78 (2013). 23976802
Roles of progesterone receptor membrane component 1 and membrane progestin receptor alpha in regulation of zebrafish oocyte maturation. Gen Comp Endocrinol. 263, 51-61 (2018). 29649418 |
Protein Accession # |
NP_000866 |
Purification |
Affinity Purified |
Nucleotide Accession # |
NM_000875 |
Tested Species Reactivity |
Human, Mouse |
Gene Symbol |
IGF1R |
Predicted Species Reactivity |
Human, Mouse, Rat, Cow, Dog, Horse, Pig, Sheep, Zebrafish |
Application |
IHC, IF, WB |
Predicted Homology Based on Immunogen Sequence |
Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 92%; Pig: 100%; Rat: 92%; Sheep: 100%; Zebrafish: 100% |
Image 1 | Human HCT116 Whole Cell
| Host: Rabbit Target Name: IGF1R Sample Tissue: Human HCT116 Whole Cell Antibody Dilution: 1ug/ml |
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Image 2 | mouse skeletal muscle
| Immunofluorescent IGF1R detection in mouse skeletal muscle (red fluorescence). Nuclei were stained with DAPI (blue fluorescence). Working dilution: 2-10 ug/ml
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Image 3 | Human Jurkat
| WB Suggested Anti-IGF1R Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: Jurkat cell lysate |
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