Product Number |
ARP90815_P050 |
Product Page |
www.avivasysbio.com/htr2b-antibody-c-terminal-region-arp90815-p050.html |
Name |
HTR2B Antibody - C-terminal region (ARP90815_P050) |
Protein Size (# AA) |
479 amino acids |
Molecular Weight |
52 kDa |
NCBI Gene Id |
15559 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
5-hydroxytryptamine (serotonin) receptor 2B |
Alias Symbols |
5-HT2B, 5-HT-2B, 5-HT-2F, AJ012488, AV377389 |
Peptide Sequence |
Synthetic peptide located within the following region: KHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLTENDGDKAEEQVSY |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Description of Target |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and downstream signaling cascades and promotes the release of Ca2+ ions from intracellular stores (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine. |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-HTR2B (ARP90815_P050) antibody |
Blocking Peptide |
For anti-HTR2B (ARP90815_P050) antibody is Catalog # AAP90815 |
Immunogen |
The immunogen is a synthetic peptide directed towards the C terminal region of mouse HTR2B |
Uniprot ID |
Q02152 |
Protein Name |
5-hydroxytryptamine receptor 2B |
Protein Accession # |
NP_032337.2 |
Purification |
Affinity purified |
Nucleotide Accession # |
NM_008311.2 |
Gene Symbol |
HTR2B |
Predicted Species Reactivity |
Mouse |
Application |
WB |
Image 1 | Mouse Lung
| Host: Rabbit Target Name: HTR2B Sample Tissue: Mouse Lung lysates Antibody Dilution: 1ug/ml |
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