| Product Number |
ARP89024_P050 |
| Product Page |
www.avivasysbio.com/xbp1-antibody-middle-region-arp89024-p050.html |
| Name |
XBP1 Antibody - middle region (ARP89024_P050) |
| Protein Size (# AA) |
371 amino acids |
| Molecular Weight |
40 kDa |
| NCBI Gene Id |
22433 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
X-box binding protein 1 |
| Alias Symbols |
TREB, XBP-, TREB-, TREB5, XBP-1, TREB-5, D11Ertd39, D11Ertd39e |
| Peptide Sequence |
Synthetic peptide located within the following region: PRAAGSEASGTPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKAR |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
Functions as a transcription factor during endoplasmic reticulum stress by regulating the unfolded protein response (UPR). Required for cardiac myogenesis and hepatogenesis during embryonic development and the development of secretory tissues such as exocrine pancreas and salivary gland. Involved in differentiation of B lymphocytes to plasma cells and production of immunoglobulins. Modulates the cellular response to ER stress in a PIK3R-dependent manner. Binds to the cis-acting X box present in the promoter regions of major histocompatibility complex class II genes (By similarity). Involved in VEGF-induced endothelial cell (EC) proliferation and retinal blood vessel formation during embryonic development but also for angiogenesis in adult tissues under ischemic conditions. Functions also as a major regulator of the UPR in obesity-induced insulin resistance and type 2 diabetes for the management of obesity and diabetes prevention. |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-XBP1 (ARP89024_P050) antibody |
| Blocking Peptide |
For anti-XBP1 (ARP89024_P050) antibody is Catalog # AAP89024 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of mouse XBP1 |
| Uniprot ID |
O35426-2 |
| Protein Name |
X-box-binding protein 1 |
| Protein Accession # |
NP_001258659.1 |
| Purification |
Affinity purified |
| Nucleotide Accession # |
NM_001271730.1 |
| Tested Species Reactivity |
Mouse |
| Gene Symbol |
XBP1 |
| Predicted Species Reactivity |
Mouse |
| Application |
WB |
| Image 1 | Mouse Heart
 | Host: Rabbit
Target Name: XBP1
Sample Tissue: Mouse Heart lysates
Antibody Dilution: 1ug/ml |
|
|
