| Product Number |
ARP88922_P050 |
| Product Page |
www.avivasysbio.com/amfr-antibody-n-terminal-region-arp88922-p050.html |
| Name |
AMFR Antibody - N-terminal region (ARP88922_P050) |
| Protein Size (# AA) |
643 amino acids |
| Molecular Weight |
70 kDa |
| NCBI Gene Id |
23802 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
autocrine motility factor receptor |
| Alias Symbols |
gp7, gp78 |
| Peptide Sequence |
Synthetic peptide located within the following region: AYRALSQPEDGSGEPEPLTAPLQPEALAPARLTAGGPRARDVAQYLLSDS |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis (By similarity). |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-AMFR (ARP88922_P050) antibody |
| Blocking Peptide |
For anti-AMFR (ARP88922_P050) antibody is Catalog # AAP88922 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of mouse AMFR |
| Uniprot ID |
Q9R049 |
| Protein Name |
E3 ubiquitin-protein ligase AMFR |
| Protein Accession # |
NP_035917.2 |
| Purification |
Affinity purified |
| Nucleotide Accession # |
NM_011787.2 |
| Tested Species Reactivity |
Mouse |
| Gene Symbol |
AMFR |
| Predicted Species Reactivity |
Mouse |
| Application |
WB |
| Image 1 | Mouse Testis
 | Host: Rabbit
Target Name: AMFR
Sample Tissue: Mouse Testis lysates
Antibody Dilution: 1ug/ml |
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