MDM2 Antibody - middle region (ARP88009_P050)

Data Sheet
 
Product Number ARP88009_P050
Product Page www.avivasysbio.com/mdm2-antibody-middle-region-arp88009-p050.html
Name MDM2 Antibody - middle region (ARP88009_P050)
Protein Size (# AA) 491 amino acids
Molecular Weight 55 kDa
NCBI Gene Id 4193
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name MDM2 proto-oncogene
Alias Symbols HDMX, LSKB, hdm2, ACTFS
Peptide Sequence Synthetic peptide located within the following region: KSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description of Target This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-MDM2 (ARP88009_P050) antibody
Blocking Peptide For anti-MDM2 (ARP88009_P050) antibody is Catalog # AAP88009
Immunogen The immunogen is a synthetic peptide directed towards the middle region of human MDM2
Uniprot ID Q00987-8
Protein Name E3 ubiquitin-protein ligase Mdm2
Protein Accession # NP_001138811.1
Purification Affinity purified
Nucleotide Accession # NM_001145339.2
Tested Species Reactivity Human
Gene Symbol MDM2
Predicted Species Reactivity Human
Application WB
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