Product Number |
ARP88009_P050 |
Product Page |
www.avivasysbio.com/mdm2-antibody-middle-region-arp88009-p050.html |
Name |
MDM2 Antibody - middle region (ARP88009_P050) |
Protein Size (# AA) |
491 amino acids |
Molecular Weight |
55 kDa |
NCBI Gene Id |
4193 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
MDM2 proto-oncogene |
Alias Symbols |
HDMX, LSKB, hdm2, ACTFS |
Peptide Sequence |
Synthetic peptide located within the following region: KSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGD |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Description of Target |
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-MDM2 (ARP88009_P050) antibody |
Blocking Peptide |
For anti-MDM2 (ARP88009_P050) antibody is Catalog # AAP88009 |
Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of human MDM2 |
Uniprot ID |
Q00987-8 |
Protein Name |
E3 ubiquitin-protein ligase Mdm2 |
Protein Accession # |
NP_001138811.1 |
Purification |
Affinity purified |
Nucleotide Accession # |
NM_001145339.2 |
Tested Species Reactivity |
Human |
Gene Symbol |
MDM2 |
Predicted Species Reactivity |
Human |
Application |
WB |
Image 1 | |
|