Product Number |
ARP81226_P050 |
Product Page |
www.avivasysbio.com/kir2ds4-antibody-n-terminal-region-arp81226-p050.html |
Name |
KIR2DS4 Antibody - N-terminal region (ARP81226_P050) |
Protein Size (# AA) |
304 amino acids |
Molecular Weight |
33 kDa |
NCBI Gene Id |
3809 |
Host |
Rabbit |
Clonality |
Polyclonal |
Concentration |
0.5 mg/ml |
Gene Full Name |
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 |
Alias Symbols |
KKA3, KIR1D, NKAT8, CD158I, KIR412, NKAT-8, KIR-2DS4 |
Peptide Sequence |
Synthetic peptide located within the following region: FLLQGAWPQEGVHRKPSFLALPGHLVKSEETVILQCWSDVMFEHFLLHRE |
Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Description of Target |
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. |
Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
Datasheets/Manuals |
Printable datasheet for anti-KIR2DS4 (ARP81226_P050) antibody |
Blocking Peptide |
For anti-KIR2DS4 (ARP81226_P050) antibody is Catalog # AAP81226 |
Immunogen |
The immunogen is a synthetic peptide directed towards the N terminal region of human KIR2DS4 |
Uniprot ID |
P43632 |
Protein Name |
killer cell immunoglobulin-like receptor 2DS4 |
Protein Accession # |
NP_001268900.1 |
Purification |
Affinity purified |
Nucleotide Accession # |
NM_001281971.1 |
Tested Species Reactivity |
Human |
Gene Symbol |
KIR2DS4 |
Predicted Species Reactivity |
Human |
Application |
WB |
Image 1 | Human Leiomyosarcoma Tumor
| Host: Rabbit Target Name: KIR2DS4 Sample Tissue: Human Leiomyosarcoma Tumor lysates Antibody Dilution: 1ug/ml |
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