| Product Number |
ARP75005_P050-FITC |
| Product Page |
www.avivasysbio.com/pnp-antibody-middle-region-fitc-arp75005-p050-fitc.html |
| Name |
PNP Antibody - middle region : FITC (ARP75005_P050-FITC) |
| Protein Size (# AA) |
289 amino acids |
| Molecular Weight |
31kDa |
| Conjugation |
FITC: Fluorescein Isothiocyanate |
| NCBI Gene Id |
4860 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Gene Full Name |
purine nucleoside phosphorylase |
| Alias Symbols |
NP, PUNP, PRO1837 |
| Peptide Sequence |
Synthetic peptide located within the following region: IMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTW |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer. |
| Reference |
N/A |
| Description of Target |
This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2. |
| Protein Interactions |
PNP; UBC; SUMO2; PPME1; SBDS; PSAT1; GMPS; RAB1A; PSMD5; MTAP; ENO2; HECW2; ITGA4; NADK2; TMEM177; DNAJB11; NDUFV1; GLO1; UBD; CDK2; SIRT7; UCHL5; LRIF1; CCDC90B; RBM48; ZHX1; TFB2M; NCALD; TFAM; TP53; APLP1; |
| Reconstitution and Storage |
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding. |
| Datasheets/Manuals |
Printable datasheet for anti-PNP (ARP75005_P050-FITC) antibody |
| Blocking Peptide |
For anti-PNP (ARP75005_P050-FITC) antibody is Catalog # AAP75005 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of Human PNPH |
| Uniprot ID |
P00491 |
| Protein Name |
purine nucleoside phosphorylase |
| Protein Accession # |
NP_000261 |
| Purification |
Affinity purified |
| Gene Symbol |
PNP |
| Predicted Species Reactivity |
Human |
| Application |
WB |
| Image 1 | |
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