| Product Number |
ARP74274_P050 |
| Product Page |
www.avivasysbio.com/tab2-antibody-middle-region-arp74274-p050.html |
| Name |
TAB2 Antibody - middle region (ARP74274_P050) |
| Protein Size (# AA) |
536 amino acids |
| Molecular Weight |
58kDa |
| NCBI Gene Id |
23118 |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Concentration |
0.5 mg/ml |
| Alias Symbols |
CHTD2, TAB-2, MAP3K7IP2 |
| Peptide Sequence |
Synthetic peptide located within the following region: SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSS |
| Product Format |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Description of Target |
The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. |
| Protein Interactions |
UBC; PIAS3; UBE2I; TRAF6; SUMO2; IRAK1; MAP3K7; TRIM38; SIK1; SIK3; TRIM22; NPM1; CST9L; SLC19A3; env; TAB1; NUMBL; IKBKG; FOSL1; ZBTB16; YWHAZ; VIM; TGM2; PPP2CB; IKBKB; GTF2I; FN1; HSP90AA1; BST2; MALT1; WDR34; APP; ESR1; MAP3K8; AR; TRIM5; TBL1XR1; MBD |
| Reconstitution and Storage |
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. |
| Datasheets/Manuals |
Printable datasheet for anti-TAB2 (ARP74274_P050) antibody |
| Blocking Peptide |
For anti-TAB2 (ARP74274_P050) antibody is Catalog # AAP74274 |
| Immunogen |
The immunogen is a synthetic peptide directed towards the middle region of Human TAB2 |
| Uniprot ID |
Q9NYJ8-2 |
| Purification |
Affinity Purified |
| Tested Species Reactivity |
Human |
| Gene Symbol |
TAB2 |
| Predicted Species Reactivity |
Human |
| Application |
WB |
| Image 1 | Human 786-0 Whole Cell
 | Host: Rabbit
Target Name: TAB2
Sample Type: 786-0 Whole Cell lysates
Antibody Dilution: 1.0ug/ml |
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