SAFB Antibody - middle region (ARP74198_P050)

Data Sheet
 
Product Number ARP74198_P050
Product Page www.avivasysbio.com/safb-antibody-middle-region-arp74198-p050.html
Name SAFB Antibody - middle region (ARP74198_P050)
Protein Size (# AA) 848 amino acids
Molecular Weight 93kDa
NCBI Gene Id 6294
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Gene Full Name scaffold attachment factor B
Alias Symbols HAP, HET, SAF-B, SAFB1, SAB-B1, SAF-B1
Peptide Sequence Synthetic peptide located within the following region: TELHGKMISVEKAKNEPVGKKTSDKRDSDGKKEKSSNSDRSTNLKRDDKC
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Description of Target This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein Interactions SUMO3; STAU1; UBC; LGR4; SUMO1; EED; rev; TP63; IL7R; CSNK2A1; MAP1LC3A; TP53BP1; TRMT112; TMOD2; RBMX; NCSTN; ACIN1; SMU1; U2AF2; CPSF6; GCN1L1; UTP14A; USP39; SAP18; VTN; U2AF1; TPBG; SURF4; SON; SRSF7; PRKAR1A; ABCC1; LAMP2; SEPT7; AK2; ACAT1; ZC3H18;
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Datasheets/Manuals Printable datasheet for anti-SAFB (ARP74198_P050) antibody
Blocking Peptide For anti-SAFB (ARP74198_P050) antibody is Catalog # AAP74198
Immunogen The immunogen is a synthetic peptide directed towards the middle region of Human SAFB1
Uniprot ID Q15424-2
Protein Name scaffold attachment factor B1
Purification Affinity Purified
Tested Species Reactivity Human
Gene Symbol SAFB
Predicted Species Reactivity Human
Application WB
Image 1
Human 786-0 Whole Cell
Host: Rabbit
Target Name: SAFB1
Sample Type: 786-0 Whole Cell lysates
Antibody Dilution: 1.0ug/ml
 

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