RASA1 Antibody - N-terminal region : FITC (ARP74173_P050-FITC)

Data Sheet
 
Product Number ARP74173_P050-FITC
Product Page www.avivasysbio.com/rasa1-antibody-n-terminal-region-fitc-arp74173-p050-fitc.html
Name RASA1 Antibody - N-terminal region : FITC (ARP74173_P050-FITC)
Protein Size (# AA) 1047 amino acids
Molecular Weight 115kDa
Conjugation FITC: Fluorescein Isothiocyanate
NCBI Gene Id 5921
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Alias Symbols GAP, PKWS, RASA, p120, CMAVM, CM-AVM, CMAVM1, RASGAP, p120GAP, p120RASGAP
Peptide Sequence Synthetic peptide located within the following region: GTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQAGK
Product Format Liquid. Purified antibody supplied in 1x PBS buffer.
Description of Target The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.
Protein Interactions ARHGAP35; DOK1; KHDRBS1; DOK2; PLCG1; EGFR; ABL1; Mbp; ERBB4; ERBB3; ERBB2; APP; SOCS1; UBC; SPSB1; ZNF579; BBS10; TRMT2A; EIF1; SERPINA4; XRCC6; EZH2; NCK1; BTRC; NFKBIA; DOK4; AFAP1L2; DNAJA3; G3BP1; PAG1; AURKB; MAP4K4; SOCS3; BIRC5; ARHGAP1; ARHGAP5;
Reconstitution and Storage All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Datasheets/Manuals Printable datasheet for anti-RASA1 (ARP74173_P050-FITC) antibody
Blocking Peptide For anti-RASA1 (ARP74173_P050-FITC) antibody is Catalog # AAP74173
Immunogen The immunogen is a synthetic peptide directed towards the N-terminal region of Human RASA1
Uniprot ID P20936
Purification Affinity purified
Gene Symbol RASA1
Predicted Species Reactivity Human
Application WB
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