DDB1 Antibody - middle region : FITC (ARP73816_P050-FITC)

Data Sheet
 
Product Number ARP73816_P050-FITC
Product Page www.avivasysbio.com/ddb1-antibody-middle-region-fitc-arp73816-p050-fitc.html
Name DDB1 Antibody - middle region : FITC (ARP73816_P050-FITC)
Protein Size (# AA) 1140 amino acids
Molecular Weight 125kDa
Conjugation FITC: Fluorescein Isothiocyanate
NCBI Gene Id 1642
Host Rabbit
Clonality Polyclonal
Concentration 0.5 mg/ml
Alias Symbols XPE, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1
Peptide Sequence Synthetic peptide located within the following region: IGIHEHASIDLPGIKGLWPLRSDPNRETDDTLVLSFVGQTRVLMLNGEEV
Product Format Liquid. Purified antibody supplied in 1x PBS buffer.
Description of Target The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
Protein Interactions SAP30; DCAF5; CUL4B; HUWE1; DCAF15; DCAF17; SAP130; DDA1; SUDS3; DCAF6; AMBRA1; DET1; PHIP; DCAF16; ARID4B; DTL; DCAF4; SIN3A; DCAF12; WDTC1; RBP1; HDAC2; HDAC1; ERCC8; UBC; CEP72; vpr; HCVgp1; CRBN; CEP57; AURKB; RFWD2; CEP250; TUBGCP2; CHEK1; CDKN1A; TP
Reconstitution and Storage All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Datasheets/Manuals Printable datasheet for anti-DDB1 (ARP73816_P050-FITC) antibody
Blocking Peptide For anti-DDB1 (ARP73816_P050-FITC) antibody is Catalog # AAP73816
Immunogen The immunogen is a synthetic peptide directed towards the middle region of Human DDB1
Uniprot ID Q16531
Protein Accession # XP_005273861
Purification Affinity Purified
Gene Symbol DDB1
Predicted Species Reactivity Human
Application WB
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